Identification of allosteric peptide agonists of CXCR4. (Q30868390)

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14 December 2019

title

Identification of allosteric peptide agonists of CXCR4 (English)

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14 December 2019

7

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14 December 2019

author name string

Aristidis Sachpatzidis

1

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14 December 2019

Benjamin K Benton

2

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14 December 2019

John P Manfredi

3

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14 December 2019

Hua Wang

4

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14 December 2019

Andrew Hamilton

5

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14 December 2019

Henrik G Dohlman

6

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14 December 2019

language of work or name

English

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publication date

3 November 2002

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Journal of Biological Chemistry

14 December 2019

published in

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14 December 2019

volume

278

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14 December 2019

issue

2

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page(s)

896-907

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Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

14 December 2019

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Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site

21 January 2018

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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

21 January 2018

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The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

21 January 2018

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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

21 January 2018

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HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

21 January 2018

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Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1.

21 January 2018

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Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptor

21 January 2018

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Human chemokines: an update

21 January 2018

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N-terminal peptides of stromal cell-derived factor-1 with CXC chemokine receptor 4 agonist and antagonist activities

21 January 2018

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Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway.

21 January 2018

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Edg-2/Vzg-1 couples to the yeast pheromone response pathway selectively in response to lysophosphatidic acid

21 January 2018

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Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast.

21 January 2018

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C5a receptor activation. Genetic identification of critical residues in four transmembrane helices

21 January 2018

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Genetic mapping of the human C5a receptor. Identification of transmembrane amino acids critical for receptor function

21 January 2018

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Functional expression of M(1), M(3) and M(5) muscarinic acetylcholine receptors in yeast

21 January 2018

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Single amino acid substitutions and deletions that alter the G protein coupling properties of the V2 vasopressin receptor identified in yeast by receptor random mutagenesis

21 January 2018

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A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists

21 January 2018

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Yeast alpha mating factor structure-activity relationship derived from genetically selected peptide agonists and antagonists of Ste2p

21 January 2018

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Strong in vitro synergy between the fusion inhibitor T-20 and the CXCR4 blocker AMD-3100.

21 January 2018

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Use of G-protein fusions to monitor integral membrane protein-protein interactions in yeast.

21 January 2018

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Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker

21 January 2018

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Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2.

21 January 2018

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The role of positively charged residues in CXCR4 recognition probed with synthetic peptides

21 January 2018

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AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.

21 January 2018

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A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140.

21 January 2018

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Caspase-dependent apoptosis of cells expressing the chemokine receptor CXCR4 is induced by cell membrane-associated human immunodeficiency virus type 1 envelope glycoprotein (gp120).

21 January 2018

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CD4-independent infection by HIV-2 is mediated by fusin/CXCR4.

21 January 2018

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Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization

21 January 2018

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Expression and functional characterization of mutant human CXCR4 in insect cells: role of cysteinyl and negatively charged residues in ligand binding

21 January 2018

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21 January 2018

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Pharmacological evidence for complex and multiple site interaction of CXCR4 with SDF-1alpha: implications for development of selective CXCR4 antagonists

21 January 2018

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Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor

21 January 2018

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A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors

21 January 2018

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CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1

21 January 2018

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Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

21 January 2018

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In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression.

21 January 2018

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A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)

21 January 2018

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The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood.

21 January 2018

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Safe use of the CXCR4 inhibitor ALX40-4C in humans

21 January 2018

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Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry

21 January 2018

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Dissociation of the signalling and antiviral properties of SDF-1-derived small peptides

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M204667200

1 reference

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14 December 2019

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