Walker, P. R.; Muzzafar, M.; Jayananda, S.; Namireddy, P.; Sharma, N.; Parent, T.; Cherry, C.; Lanman, R. B. Plasma Cell-free RNA PD-L1 Expression and Overall Survival of Immune Checkpoint Inhibitor Therapy in Advanced Non-Small Cell Lung Cancer. Preprints2022, 2022080208. https://doi.org/10.20944/preprints202208.0208.v1
APA Style
Walker, P. R., Muzzafar, M., Jayananda, S., Namireddy, P., Sharma, N., Parent, T., Cherry, C., & Lanman, R. B. (2022). Plasma Cell-free RNA PD-L1 Expression and Overall Survival of Immune Checkpoint Inhibitor Therapy in Advanced Non-Small Cell Lung Cancer. Preprints. https://doi.org/10.20944/preprints202208.0208.v1
Chicago/Turabian Style
Walker, P. R., Cynthia Cherry and Richard B. Lanman. 2022 "Plasma Cell-free RNA PD-L1 Expression and Overall Survival of Immune Checkpoint Inhibitor Therapy in Advanced Non-Small Cell Lung Cancer" Preprints. https://doi.org/10.20944/preprints202208.0208.v1
Abstract
Tissue programmed death ligand-1 (PD-L1) protein expression is predictive of immune checkpoint inhibitor (ICI) benefit. However, tissue PD-L1 can be fraught with tissue acquisition and heterogeneity limitations. Plasma testing can overcome these limitations. However, the overall survival (OS) predictive benefit of plasma PD-L1 assays have not been well characterized. Patients with stage IV non-small cell lung cancer (NSCLC) and plasma cfRNA PD-L1 by PCR expression were identified and assessed for OS. 16 patients treated with front-line ICI-based regimens were assessed and represented a real-world patient population with over half with a performance status of 2 or greater. 10 contemporaneous patients at the same institution treated with chemotherapy alone were also identified and assessed. With a median follow-up of 33 months, median OS was 13 months with a 30% 3-year OS for the ICI treated patients compared to a median OS of 3 months and a 10% 3-year OS for those treated with chemotherapy alone. Comparative log-rank test p-value = 0.014 and a hazard ratio 0.376 (95%-CI 0.134-1.057). Plasma cfRNA PD-L1 was associated with a statistically significant survival benefit from ICI-based treatment compared to chemotherapy in the first line treatment of a real-world patient population of advanced NSCLC.
Medicine and Pharmacology, Oncology and Oncogenics
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