Version 1
: Received: 19 June 2021 / Approved: 23 June 2021 / Online: 23 June 2021 (11:25:28 CEST)
How to cite:
Farooq, U.; Shah, S. A.; Khan, T.; Ullah, R.; Raziq, N.; Shahid, M.; Khusro, A.; Sahibzada, M. U. K.; Seidel, V.; Alkhedaide, A.; Batiha, G. E.-S.; Koirala, N. Neuroprotective Efficacy of Folecitin From Hypericum Oblongifolium Against LPS-Induced Oxidative Stress, Neurodegeneration, and Memory Dysfunction. Preprints2021, 2021060576. https://doi.org/10.20944/preprints202106.0576.v1
Farooq, U.; Shah, S. A.; Khan, T.; Ullah, R.; Raziq, N.; Shahid, M.; Khusro, A.; Sahibzada, M. U. K.; Seidel, V.; Alkhedaide, A.; Batiha, G. E.-S.; Koirala, N. Neuroprotective Efficacy of Folecitin From Hypericum Oblongifolium Against LPS-Induced Oxidative Stress, Neurodegeneration, and Memory Dysfunction. Preprints 2021, 2021060576. https://doi.org/10.20944/preprints202106.0576.v1
Farooq, U.; Shah, S. A.; Khan, T.; Ullah, R.; Raziq, N.; Shahid, M.; Khusro, A.; Sahibzada, M. U. K.; Seidel, V.; Alkhedaide, A.; Batiha, G. E.-S.; Koirala, N. Neuroprotective Efficacy of Folecitin From Hypericum Oblongifolium Against LPS-Induced Oxidative Stress, Neurodegeneration, and Memory Dysfunction. Preprints2021, 2021060576. https://doi.org/10.20944/preprints202106.0576.v1
APA Style
Farooq, U., Shah, S. A., Khan, T., Ullah, R., Raziq, N., Shahid, M., Khusro, A., Sahibzada, M. U. K., Seidel, V., Alkhedaide, A., Batiha, G. E. S., & Koirala, N. (2021). Neuroprotective Efficacy of Folecitin From Hypericum Oblongifolium Against LPS-Induced Oxidative Stress, Neurodegeneration, and Memory Dysfunction. Preprints. https://doi.org/10.20944/preprints202106.0576.v1
Chicago/Turabian Style
Farooq, U., Gaber El-Saber Batiha and Niranjan Koirala. 2021 "Neuroprotective Efficacy of Folecitin From Hypericum Oblongifolium Against LPS-Induced Oxidative Stress, Neurodegeneration, and Memory Dysfunction" Preprints. https://doi.org/10.20944/preprints202106.0576.v1
Abstract
Neurological disorders, such as amyotrophic lateral sclerosis, Parkinson’s disease, and Alzheimer’s disease, are commonly associated with persistent neuro-inflammation, and there is an urgent need to discover new therapeutic agents that may target the various pathways involved in neurodegeneration. In this study, we investigated the therapeutic potential of folecitin, a flavonoid isolated from Hypericum oblongifolium, against lipopolysaccharide (LPS)-induced oxidative stress associated with neurodegeneration, amyloidogenic Aβ production pathway, and memory dysfunction in mice. LPS was administered i.p. at 250 µg/kg/day for 3 weeks, followed by the administration of folecitin at a dose of 30 mg/kg/day for the last two weeks. A Western blot technique was used to assess the expression of different proteins involved in oxidative stress, neurodegeneration, and neuronal synapse. Results indicated that folecitin significantly reduced LPS-induced apoptotic neurodegeneration, including the expression of BAX, Caspase-3, and PARP-1 proteins, inhibited BACE1, and the amyloidogenic Aβ production pathway. Folecitin improved both pre- and post-neuronal synapse, as well as memory dysfunction. Furthermore, folecitin significantly activated endogenous antioxidant proteins such as Nrf-2 and HO-1 via stimulating the phosphorylation of Akt proteins. These findings suggest that folecitin may be a suitable lead to design new drugs for neurotoxin-triggered neurodegenerative disorders.
Chemistry and Materials Science, Analytical Chemistry
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