Woman with big belly

See the weight-loss transformations from this season of My 600lb Life

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Record breaking mother-of-two Donna Simpson, who weighed 600 pounds, decided to start losing weight after she broke up with her feeder future husband.

Megan Fisher, 29, who lives in New York City, has never felt confident in her appearance, and spent years following fad diets to try and slim down.

Photo about a fat woman who cannot fit into her jeans. Image of belly, desire, meter - 9905658

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Twin pregnancy belly

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Natalie Vargas, 31, from Los Angeles, has battled obesity for years, however she reached breaking point when doctors warned she was facing early death.