AAO 2024: Key Insights on Wet AMD

Arshad M. Khanani, MD, MA

Disclosures

November 04, 2024

Dr Arshad Khanani reports on several compelling talks given at the neovascular AMD session at AAO 2024. Dr Barbara Blodi presented higher rates of macular atrophy in patients treated with anti-VEGF compared with sham treatments in the MARINA study. Dr Usha Chakravarthy emphasized the need for consensus on fibrosis biomarkers to improve visual acuity outcomes, while Dr Gemmy Cheung found that combination therapies with photodynamic treatment could optimize results for patients with polypoidal choroidal vasculopathy.

Turning toward a different aspect of research, Dr Marco Zarbin highlighted how different re-treatment criteria in phase 3 clinical trials can significantly affect durability outcomes. His analysis showed that varying the criteria from "and" to "or" can lead to notable differences in patient outcomes, underscoring the importance of these criteria in interpreting clinical trial data.

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