| Entry |
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| Name |
BCR-ABL fusion kinase to RAS-ERK signaling pathway
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| Definition |
BCR-ABL -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK |
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| Expanded |
(25v1,25v2) -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
| H00004 | Chronic myeloid leukemia |
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| Gene |
| 25 | ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase |
| 2885 | GRB2; growth factor receptor bound protein 2 |
| 6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
| 6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
| 673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
| 5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
| 5594 | MAPK1; mitogen-activated protein kinase 1 |
| 5595 | MAPK3; mitogen-activated protein kinase 3 |
|
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| Variant |
25v1 (BCR-ABL) BCR-ABL1 fusion
25v2 (BCR-ABL) First generation TKI-resistant ABL1 mutation
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| Reference |
|
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| Authors |
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM. |
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| Title |
The biology of chronic myeloid leukemia. |
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| Journal |
|
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| Reference |
|
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| Authors |
Deininger MW, Goldman JM, Melo JV. |
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| Title |
The molecular biology of chronic myeloid leukemia. |
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| Journal |
Blood 96:3343-56 (2000) |
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| Reference |
|
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| Authors |
Calabretta B, Perrotti D. |
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| Title |
The biology of CML blast crisis. |
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| Journal |
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| LinkDB |
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