Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells
AMD Machado, C Desler, S Bøggild… - Mechanisms of ageing …, 2013 - Elsevier
Helicobacter pylori infection is an important factor for the development of atrophic gastritis
and gastric carcinogenesis. However, the mechanisms explaining the effects of H. pylori
infection are not fully elucidated. H. pylori infection is known to induce genetic instability in
both nuclear and mitochondrial DNA of gastric epithelial cells. The mutagenic effect of H.
pylori infection on nuclear DNA is known to be a consequence, in part, of a down-regulation
of expression and activity of major DNA repair pathways. In this study, we demonstrate that …
and gastric carcinogenesis. However, the mechanisms explaining the effects of H. pylori
infection are not fully elucidated. H. pylori infection is known to induce genetic instability in
both nuclear and mitochondrial DNA of gastric epithelial cells. The mutagenic effect of H.
pylori infection on nuclear DNA is known to be a consequence, in part, of a down-regulation
of expression and activity of major DNA repair pathways. In this study, we demonstrate that …