Long noncoding RNAs in cancer pathways
AM Schmitt, HY Chang - Cancer cell, 2016 - cell.com
AM Schmitt, HY Chang
Cancer cell, 2016•cell.comGenome-wide cancer mutation analyses are revealing an extensive landscape of functional
mutations within the noncoding genome, with profound effects on the expression of long
noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can
provide signals of malignant transformation, we now understand that lncRNAs drive many
important cancer phenotypes through their interactions with other cellular macromolecules
including DNA, protein, and RNA. Recent advancements in surveying lncRNA molecular …
mutations within the noncoding genome, with profound effects on the expression of long
noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can
provide signals of malignant transformation, we now understand that lncRNAs drive many
important cancer phenotypes through their interactions with other cellular macromolecules
including DNA, protein, and RNA. Recent advancements in surveying lncRNA molecular …
Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand that lncRNAs drive many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, protein, and RNA. Recent advancements in surveying lncRNA molecular mechanisms are now providing the tools to functionally annotate these cancer-associated transcripts, making these molecules attractive targets for therapeutic intervention in the fight against cancer.
cell.com