Double-strand break end resection and repair pathway choice
LS Symington, J Gautier - Annual review of genetics, 2011 - annualreviews.org
DNA double-strand breaks (DSBs) are cytotoxic lesions that can result in mutagenic events
or cell death if left unrepaired or repaired inappropriately. Cells use two major pathways for
DSB repair: nonhomologous end joining (NHEJ) and homologous recombination (HR). The
choice between these pathways depends on the phase of the cell cycle and the nature of the
DSB ends. A critical determinant of repair pathway choice is the initiation of 5′-3′
resection of DNA ends, which commits cells to homology-dependent repair, and prevents …
or cell death if left unrepaired or repaired inappropriately. Cells use two major pathways for
DSB repair: nonhomologous end joining (NHEJ) and homologous recombination (HR). The
choice between these pathways depends on the phase of the cell cycle and the nature of the
DSB ends. A critical determinant of repair pathway choice is the initiation of 5′-3′
resection of DNA ends, which commits cells to homology-dependent repair, and prevents …
