Pedro Pascal was originally cast but dropped out for undisclosed reasons and was replaced by Leonardo Sbaraglia.
Penélope Cruz and Edgar Ramírez play a couple in this film. They previously played brother and sister in the second season of American Crime Story (2016).
Edgar Ramírez and Ana de Armas were also in Hands of Stone (2016) together, where they played husband and wife Roberto and Felicidad Duran.
Wagner Moura acted as Pablo Escobar in Narcos (2015). In this movie he mentions Escobar.