Ranked 28th in Jerry Beck's 1994 book "The 50 Greatest Cartoons: As Selected by 1,000 Animation Professionals".
Alka-Fizz is both a play on Alcatraz Prison as well as the fizzy bicarbonate of soda indigestion remedies (Alka Seltzer, Bromo Seltzer, etc.) of the time.
The series of message signs are modeled after the famous Burma Shave road advertising campaign of the era. They were spaced along busily traversed roads at various intervals, and told a story in rhyme that promoted Burma Shave shaving cream.
The notion of changing one's appearance via plastic surgery was a common plot element in films of the time. It would feature in Dark Passage the following year (1947), with Humphrey Bogart going under the surgeon's scalpel.
As originally released, this was the final MGM cartoon to use the sunburst MGM logo intro.