Stanley Ho est né le 25 novembre 1921 à Hong Kong, British Overseas Territory (now Hong Kong, China). Il était marié à Clementina Angela Leitão, Leong On-kei, Lucina Azul Jean Ying et Ina Chan. Il est mort le 26 mai 2020 à Hong Kong.
He held a four-decade monopoly on casinos in Macau until it opened to foreign companies in 2002. He was the wealthiest person in the former Portuguese colony.