- In 2000, they filmed a movie titled after their fourth album, "Murda Muzik", about gang life in Queensbridge. However, it was not released until 2004 due to a lack of funding and promotion after their original label, Loud Records, shut down.
- Prodigy suffers from Sickle Cell Anemia. In 2002, Mobb Deep had to cancel an overseas tour because he was hospitalized after a bout with the disease. On the song "You Can Never Feel My Pain" from his solo album "H.N.I.C.", Prodigy raps about his experiences with Sickle Cell, both in his childhood and adult life.
- Prodigy finishes writing his memoirs in prison while Havoc prepares beats for his release. The two amicably leave G-Unit records for an independent deal. (May 2010)
- Signed to 50 Cent's record label, G-Unit (2005)
- NYC: Released a comeback EP 'Black Cocaine', their first release since Prodigy's jail time. The work features a reunion track with Nas, a once long-time collaborator. (November 2011)
- Released their new album 'Blood Money' on May 2nd, 2006. They are scheduled to perform at New York hip-hop/R&B radio station Hot 97's Summer Jam 2006 concert in June. (May 2006)
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