- He died on November 22, 1963, the same day that C.S. Lewis died of kidney failure and President John F. Kennedy was shot to death in Dallas, Texas.
- He got his wife to inject him with pure LSD on his death bed.
- The legendary American rock band The Doors took their name from Huxley's "The Doors of Perception".
- He appears on the cover of The Beatles' "Sgt. Pepper's Lonely Hearts Club Band".
- His friend J.B.S. Haldane's ideas regarding artificial wombs, ectogenesis, and ectogens influenced his novel Brave New World (1932).
- In the book "The Day of the Triffids" by John Wyndham, it mentions Huxley, the author of "Brave New World", which applies to the story with its themes of a parallel future.
- His grandfather, Thomas Henry Huxley, was a biologist famous as one of the earliest and most vocal supporters of Charles Darwin's theory of evolution.
- He allegedly declined a British knighthood in 1959.
- He has a First in English from Balliol, Oxford. He was one of only two people that year to gain a First. He was also winner of the Stanhope essay prize.
- He had one son: Matthew Huxley (1920-2005).
- He is mentioned in the Sheryl Crow song "Run Baby Run".
- He allegedly declined knighthood of the British Empire in 1959 for his services to literature.
- He was the grandfather of Trevenen Huxley and Tessa Huxley.
- He was the brother of Julian Huxley, Trevenen Huxley and half-brother of Andrew Huxley and David Huxley.
- He was the son of Leonard Huxley (1860-1933) and Julia Frances Arnold.
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