- His father, comedian Freddie Prinze, committed suicide when young Freddie was 10 months old. He was raised by his mother and grandmother.
- As a fan of pop culture, he initially turned down Raja Gosnell's offer to star with real life love Sarah Michelle Gellar in Scooby-Doo (2002) because he felt it would not be respecting the original series, but Sarah talked him into it.
- Holds black belts in American kenpo karate and American tang soo do karate, and a blue belt in Gracie/Brazilian jiu-jitsu.
- First met Sarah Michelle Gellar on the movie set of I Know What You Did Last Summer (1997).
- Wife, Sarah Michelle Gellar, gave birth to their second child, a son named Rocky James Prinze, on September 19, 2012.
- Had to shave his head after filming Scooby-Doo (2002) because the bleach ruined his hair.
- Freddie and Sarah Michelle Gellar became the parents of a girl, Charlotte Grace Prinze, on September 19, 2009 in Los Angeles.
- He grew up in New Mexico but spent the summers in Puerto Rico with his paternal grandmother.
- Freddie's paternal grandfather, Edward Karl Pruetzel, was German, born in 1914 in Berlin, to Friedrich Karl Prutzel and Eleanor Maria Magdelena Schultes. Edward moved to the United States in 1934. Freddie's paternal grandmother, María de Gracia "Mare" Graniela y Ramirez, was Puerto Rican. Freddie's mother, whose family is from West Virginia, has Irish, English, Scottish, German, Austrian, and Swiss-German ancestry.
- Enjoys martial arts, swimming and tap dancing.
- Said the hardest part about filming Scooby-Doo (2002) (aside from being homesick) was that he had to constantly re-dye his jet black hair blonde to match his character, Fred.
- Collects comic books.
- Worked for World Wrestling Entertainment as a member of the creative team from July 28th, 2008 to February 2009.
- As of 2004, has worked (co-starred) with actor Matthew Lillard 5 times: Wing Commander (1999), Summer Catch (2001), She's All That (1999), Scooby-Doo (2002), and Scooby-Doo 2: Monsters Unleashed (2004).
- Was suppose to be in I'll Always Know What You Did Last Summer (2006) with Brandy and Jennifer again, but then they changed the script and left them out.
- Bought a $3 million, 5-bedroom, 4000 square foot house in the San Fernando Valley. (September 2000)
- His godfather is martial arts legend Robert Wall.
- Auditioned for the role of Stu in Scream (1996).
- Son of Freddie Prinze and Katherine Elaine Cochrane-Prinze (Kathy Prinze).
- Was a "Junior Golden Gloves" winner as a teenager.
- Graduated from La Cueva High School, Albuquerque, New Mexico in 1994.
- In March 2006, he ran his first marathon (The Los Angeles Marathon XXI) with a 05:50:49 finishing time using the name "Freddie James".
- Lindsay Sloane was maid of honor at his wedding to Sarah Michelle Gellar
- Named one of "People" magazine's 50 Most Beautiful People in 2000.
- Has the same manager as Jared Padalecki.
- On People's (USA) 'Best-Dressed' list. (September 2000)
- Born at 7:38PM (PST).
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