 |
This article is an orphan, as few or no other articles link to it. Please introduce links to this page from related articles; suggestions may be available. (February 2009) |
| Neural precursor cell expressed, developmentally down-regulated 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | NEDD1; GCP-WD; TUBGCP7 | ||||||||||
| External IDs | OMIM: 600372 MGI: 97293 HomoloGene: 7439 GeneCards: NEDD1 Gene | ||||||||||
|
|||||||||||
| RNA expression pattern | |||||||||||
 |
|||||||||||
 |
|||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 121441 | 17997 | |||||||||
| Ensembl | ENSG00000139350 | ENSMUSG00000019988 | |||||||||
| UniProt | Q8NHV4 | P33215 | |||||||||
| RefSeq (mRNA) | NM_001135175.1 | NM_008682.2 | |||||||||
| RefSeq (protein) | NP_001128647.1 | NP_032708.2 | |||||||||
| Location (UCSC) | Chr 12: 97.3 – 97.35 Mb |
Chr 10: 92.15 – 92.19 Mb |
|||||||||
| PubMed search | [1] | [2] | |||||||||
Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene [1] and encodes the protein NEDD1.
NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation.
References [link]
Further reading [link]
- Haren L, Remy MH, Bazin I, et al. (2006). "NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly.". J. Cell Biol. 172 (4): 505–15. DOI:10.1083/jcb.200510028. PMC 2063671. PMID 16461362. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2063671.
- Lüders J, Patel UK, Stearns T (2006). "GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation.". Nat. Cell Biol. 8 (2): 137–47. DOI:10.1038/ncb1349. PMID 16378099.
- Jung SY, Malovannaya A, Wei J, et al. (2005). "Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.". Mol. Endocrinol. 19 (10): 2451–65. DOI:10.1210/me.2004-0476. PMID 16051665.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Takai S, Yoshida Y, Noda M, et al. (1995). "Assignment of the developmentally regulated gene NEDD1 to human chromosome 12q22 by fluorescence in situ hybridization.". Hum. Genet. 95 (1): 96–8. DOI:10.1007/BF00225082. PMID 7814034.
 |
This article on a gene on chromosome 12 is a stub. You can help Wikipedia by expanding it. |
https://wn.com/NEDD1
Podcasts:
Fly
by: Nate TaoGot a call
From a friend.
Tried to smile
As I lay in my bed.
All I heard
Where the voices in my head.
Why do you
Have to be
So much more
Then I could hope for me.
Honestly, all I feel is jealously.
And I know that it's wrong
My dreams were at a long
So there's no need to fight this battle every night
Cause I will get there
I have what it takes to survive.
It's over! Glad it's over!
All the doubts and questions in my head.
I'm better off without instead
Now or never, so I just gotta try
To the man I was today I say goodbye.
Tomorrow I will fly, fly, fly.
Watch me fly, fly, fly.
When they talk
When they stare.
It feels just,
Like I'm not even there.
And I say, that I don't really care.
But the truth is that it
Gets to me and it shakes my belief
In myself am what I aim to be
And I know that it's wrong
My dreams were at a long
So there's no need to fight this battle every night
Cause I will get there
I have what it takes to survive.
It's over! Glad it's over!
All the doubts and questions in my head.
I'm better off without instead
Now or never, so I just gotta try
To the man I was today I say goodbye.
And now the finish line
Seems a distant side.
But imma put my eye
On the final prize.
However it longs to takes
I will bend or break, cause this could be, the moment of my life.
It's over! Glad it's over!
All the doubts and questions in my head.
I'm better off without instead
Now or never, so I just gotta try
To the man I was today I say goodbye.
Tomorrow I will fly, fly, fly.
Watch me fly, fly, fly.
Watch me fly, fly, fly.