Hoopers Lake Water Aerodrome

Hoopers Lake Water Aerodrome (TC LID: CDT2) is located in Deerfield, Nova Scotia, Canada and is open from April to November.

References

Bouctouche Aerodrome

Bouctouche Aerodrome (TC LID: CDT5) is a privately owned airfield located 1.7 nautical miles (3.1 km; 2.0 mi) northeast of Bouctouche, New Brunswick, Canada. The aerodrome is listed in the Canada Flight Supplement as Buctouche.

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DNA replication factor CDT1

DNA replication factor Cdt1 is a protein that in humans is encoded by the CDT1 gene.

The protein encoded by this gene is a key licensing factor which, along with the protein Cdc6, functions to license DNA by forming the pre-replication complex (pre-RC). Its activity during the cell cycle is tightly regulated by its association with the protein geminin, which both inhibits Cdt1 activity during S phase in order to prevent re-replication of DNA and prevents it from ubiquitination and subsequent proteolysis.

Orthologs

CDT1 belongs to a family of replication proteins conserved from yeast to humans. Examples of orthlogs in other species include:

Interactions

DNA replication factor CDT1 has been shown to interact with SKP2. Cdt1 is recruited by the origin recognition complex in origin licensing. Null-mutations for Cdt1 are lethal in yeast; the spores undergo mitosis without DNA replication. The overexpression of Cdt1 causes rereplication in H. sapiens, which activates the Chk1 pathway, preventing entry into mitosis.