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Bioenergetic Origins of Complexity and Disease
- D.C. Wallace
Cold Spring Harb Symp Quant Biol 2011 76: 1-16; Published in Advance December 22, 2011, doi:10.1101/sqb.2011.76.010462
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Nuclear Receptors and AMPK: Resetting Metabolism
- W. Fan,
- M. Downes,
- A. Atkins,
- R. Yu,
- and R.M. Evans
Cold Spring Harb Symp Quant Biol 2011 76: 17-22; Published in Advance March 12, 2012, doi:10.1101/sqb.2012.76.010470
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Rethinking the Regulation of Cellular Metabolism
- C.B. Thompson
Cold Spring Harb Symp Quant Biol 2011 76: 23-29; Published in Advance March 19, 2012, doi:10.1101/sqb.2012.76.010496

Clocks and Rhythms

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The Time of Metabolism: NAD⁺, SIRT1, and the Circadian Clock
- M.M. Bellet,
- R. Orozco-Solis,
- S. Sahar,
- K. Eckel-Mahan,
- and P. Sassone-Corsi
Cold Spring Harb Symp Quant Biol 2011 76: 31-38; Published in Advance December 16, 2011, doi:10.1101/sqb.2011.76.010520
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The Mammalian Circadian Timing System: Synchronization of Peripheral Clocks
- C. Saini,
- D.M. Suter,
- A. Liani,
- P. Gos,
- and U. Schibler
Cold Spring Harb Symp Quant Biol 2011 76: 39-47; Published in Advance December 16, 2011, doi:10.1101/sqb.2011.76.010918
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Circadian Epigenomic Remodeling and Hepatic Lipogenesis: Lessons from HDAC3
- Z. Sun,
- D. Feng,
- L.J. Everett,
- A. Bugge,
- and M.A. Lazar
Cold Spring Harb Symp Quant Biol 2011 76: 49-55; Published in Advance September 6, 2011, doi:10.1101/sqb.2011.76.011494
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Estrogen-Related Receptor α, the Molecular Clock, and Transcriptional Control of Metabolic Outputs
- V. Giguère,
- C.R. Dufour,
- L.J. Eichner,
- G. Deblois,
- and N. Cermakian
Cold Spring Harb Symp Quant Biol 2011 76: 57-61; Published in Advance December 16, 2011, doi:10.1101/sqb.2011.76.011031
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Circadian Clocks in Fuel Harvesting and Energy Homeostasis
- K.M. Ramsey and
- J. Bass
Cold Spring Harb Symp Quant Biol 2011 76: 63-72; Published in Advance September 2, 2011, doi:10.1101/sqb.2011.76.010546

Life Span and Aging

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Gamete Formation Resets the Aging Clock in Yeast
- E. Ünal and
- A. Amon
Cold Spring Harb Symp Quant Biol 2011 76: 73-80; Published in Advance September 2, 2011, doi:10.1101/sqb.2011.76.011379
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Sirtuins, Aging, and Metabolism
- Leonard Guarente
Cold Spring Harb Symp Quant Biol 2011 76: 81-90; Published in Advance November 23, 2011, doi:10.1101/sqb.2011.76.010629
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The Heat Shock Response: Systems Biology of Proteotoxic Stress in Aging and Disease
- Richard I. Morimoto
Cold Spring Harb Symp Quant Biol 2011 76: 91-99; Published in Advance February 27, 2012, doi:10.1101/sqb.2012.76.010637
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Skeletal Muscle Stem Cells: Effects of Aging and Metabolism on Muscle Regenerative Function
- Y.C. Jang,
- M. Sinha,
- M. Cerletti,
- C. Dall'Osso,
- and A.J. Wagers
Cold Spring Harb Symp Quant Biol 2011 76: 101-111; Published in Advance September 29, 2011, doi:10.1101/sqb.2011.76.010652
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The C. elegans DAF-2 Insulin-Like Receptor is Abundantly Expressed in the Nervous System and Regulated by Nutritional Status
- K.D. Kimura,
- D.L. Riddle,
- and G. Ruvkun
Cold Spring Harb Symp Quant Biol 2011 76: 113-120; Published in Advance November 28, 2011, doi:10.1101/sqb.2011.76.010660

Regulation and Dysregulation of Metabolism

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Surviving Starvation: Essential Role of the Ghrelin-Growth Hormone Axis
- J.L. Goldstein,
- T.-j. Zhao,
- R.L. Li,
- D.P. Sherbet,
- G. Liang,
- and M.S. Brown
Cold Spring Harb Symp Quant Biol 2011 76: 121-127; Published in Advance July 22, 2011, doi:10.1101/sqb.2011.76.010447
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Transcriptional and Posttranscriptional Control of Cholesterol Homeostasis by Liver X Receptors
- P. Tontonoz
Cold Spring Harb Symp Quant Biol 2011 76: 129-137; Published in Advance August 22, 2011, doi:10.1101/sqb.2011.76.010702
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Roles of FGF19 in Liver Metabolism
- S. Kir,
- S.A. Kliewer,
- and D.J. Mangelsdorf
Cold Spring Harb Symp Quant Biol 2011 76: 139-144; Published in Advance August 3, 2011, doi:10.1101/sqb.2011.76.010710
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A New Approach to an Old Problem: Synthetic Biology Tools for Human Disease and Metabolism
- D.R. Burrill,
- P.M. Boyle,
- and P.A. Silver
Cold Spring Harb Symp Quant Biol 2011 76: 145-154; Published in Advance December 14, 2011, doi:10.1101/sqb.2011.76.010686

Signaling and Gene Regulation

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Adenosine Monophosphate–Activated Protein Kinase: A Central Regulator of Metabolism with Roles in Diabetes, Cancer, and Viral Infection
- D.G. Hardie
Cold Spring Harb Symp Quant Biol 2011 76: 155-164; Published in Advance November 9, 2011, doi:10.1101/sqb.2011.76.010819
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Regulated Histone Methyltransferase and Demethylase Complexes in the Control of Genes by Nuclear Receptors
- A. Yokoyama,
- R. Fujiki,
- F. Ohtake,
- and S. Kato
Cold Spring Harb Symp Quant Biol 2011 76: 165-173; Published in Advance September 2, 2011, doi:10.1101/sqb.2011.76.010736
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Transcriptional Control of Cardiac Fuel Metabolism and Mitochondrial Function
- T.C. Leone and
- D.P. Kelly
Cold Spring Harb Symp Quant Biol 2011 76: 175-182; Published in Advance November 17, 2011, doi:10.1101/sqb.2011.76.011965
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Metabolic Specialization of Mouse Embryonic Stem Cells
- J. Wang,
- P. Alexander,
- and S.L. McKnight
Cold Spring Harb Symp Quant Biol 2011 76: 183-193; Published in Advance November 9, 2011, doi:10.1101/sqb.2011.76.010835
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On Acetyl-CoA as a Gauge of Cellular Metabolic State
- L. Cai and
- B.P. Tu
Cold Spring Harb Symp Quant Biol 2011 76: 195-202; Published in Advance September 6, 2011, doi:10.1101/sqb.2011.76.010769

Metabolic Reprogramming

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Nutrient-Dependent Acetylation Controls Basic Regulatory Metabolic Switches and Cellular Reprogramming
- J.E. Dominy,
- Z. Gerhart-Hines,
- and P. Puigserver
Cold Spring Harb Symp Quant Biol 2011 76: 203-209; Published in Advance February 27, 2012, doi:10.1101/sqb.2012.76.010843
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Control of Glycolysis through Regulation of PFK1: Old Friends and Recent Additions
- I. Mor,
- E.C. Cheung,
- and K.H. Vousden
Cold Spring Harb Symp Quant Biol 2011 76: 211-216; Published in Advance November 17, 2011, doi:10.1101/sqb.2011.76.010868
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ENTPD5, an Endoplasmic Reticulum UDPase, Alleviates ER Stress Induced by Protein Overloading in AKT-Activated Cancer Cells
- Z. Shen,
- S. Huang,
- M. Fang,
- and X. Wang
Cold Spring Harb Symp Quant Biol 2011 76: 217-223; Published in Advance December 14, 2011, doi:10.1101/sqb.2011.76.010876
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MicroRNAs in Metabolism and Metabolic Diseases
- V. Rottiers,
- S.H. Najafi-Shoushtari,
- F. Kristo,
- S. Gurumurthy,
- L. Zhong,
- Y. Li,
- D.E. Cohen,
- R.E. Gerszten,
- N. Bardeesy,
- R. Mostoslavsky,
- and A.M. Näär
Cold Spring Harb Symp Quant Biol 2011 76: 225-233; Published in Advance December 12, 2011, doi:10.1101/sqb.2011.76.011049
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Metabolomics in Drug Target Discovery
- J.D. Rabinowitz,
- J.G. Purdy,
- L. Vastag,
- T. Shenk,
- and E. Koyuncu
Cold Spring Harb Symp Quant Biol 2011 76: 235-246; Published in Advance November 23, 2011, doi:10.1101/sqb.2011.76.010694

Fat, Intermediary Metabolism, and Exercise

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Transcriptional Networks Controlling Adipocyte Differentiation
- R. Siersbæk and
- S. Mandrup
Cold Spring Harb Symp Quant Biol 2011 76: 247-255; Published in Advance September 6, 2011, doi:10.1101/sqb.2011.76.010512
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Adiponectin, Adiponectin Receptors, and Epigenetic Regulation of Adipogenesis
- T. Kadowaki,
- T. Yamauchi,
- H. Waki,
- M. Iwabu,
- M. Okada-Iwabu,
- and M. Nakamura
Cold Spring Harb Symp Quant Biol 2011 76: 257-265; Published in Advance April 4, 2012, doi:10.1101/sqb.2012.76.010587
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SIRT3 Regulates Mitochondrial Protein Acetylation and Intermediary Metabolism
- M.D. Hirschey,
- T. Shimazu,
- J.-Y. Huang,
- B. Schwer,
- and E. Verdin
Cold Spring Harb Symp Quant Biol 2011 76: 267-277; Published in Advance November 23, 2011, doi:10.1101/sqb.2011.76.010850
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Regulation of Male Fertility by Bone
- G. Karsenty
Cold Spring Harb Symp Quant Biol 2011 76: 279-283; Published in Advance August 22, 2011, doi:10.1101/sqb.2011.76.010934
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Regulation of Glycolysis and Gluconeogenesis by Acetylation of PKM and PEPCK
- Y. Xiong,
- Q-Y. Lei,
- S. Zhao,
- and K-L. Guan
Cold Spring Harb Symp Quant Biol 2011 76: 285-289; Published in Advance November 17, 2011, doi:10.1101/sqb.2011.76.010942
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NAD⁺ as a Signaling Molecule Modulating Metabolism
- C. Cantó and
- J. Auwerx
Cold Spring Harb Symp Quant Biol 2011 76: 291-298; Published in Advance February 17, 2012, doi:10.1101/sqb.2012.76.010439

Metabolism and Cancer

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Cancer Cell Metabolism
- R.A. Cairns,
- I. Harris,
- S. McCracken,
- and T.W. Mak
Cold Spring Harb Symp Quant Biol 2011 76: 299-311; Published in Advance December 12, 2011, doi:10.1101/sqb.2011.76.012856
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Extracellular Matrix Regulation of Metabolism and Implications for Tumorigenesis
- A.R. Grassian,
- J.L. Coloff,
- and J.S. Brugge
Cold Spring Harb Symp Quant Biol 2011 76: 313-324; Published in Advance November 21, 2011, doi:10.1101/sqb.2011.76.010967
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Metabolic Pathway Alterations that Support Cell Proliferation
- M.G. Vander Heiden,
- S.Y. Lunt,
- T.L. Dayton,
- B.P. Fiske,
- W.J. Israelsen,
- K.R. Mattaini,
- N.I. Vokes,
- G. Stephanopoulos,
- L.C. Cantley,
- C.M. Metallo,
- and J.W. Locasale
Cold Spring Harb Symp Quant Biol 2011 76: 325-334; Published in Advance January 19, 2012, doi:10.1101/sqb.2012.76.010900
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Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases
- W.G. Kaelin, Jr.
Cold Spring Harb Symp Quant Biol 2011 76: 335-345; Published in Advance November 16, 2011, doi:10.1101/sqb.2011.76.010975
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Regulation of Metabolism by Hypoxia-Inducible Factor 1
- G.L. Semenza
Cold Spring Harb Symp Quant Biol 2011 76: 347-353; Published in Advance July 22, 2011, doi:10.1101/sqb.2011.76.010678
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mRNA Translation and Energy Metabolism in Cancer: The Role of the MAPK and mTORC1 Pathways
- I. Topisirovic and
- N. Sonenberg
Cold Spring Harb Symp Quant Biol 2011 76: 355-367; Published in Advance November 28, 2011, doi:10.1101/sqb.2011.76.010785
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Therapeutic Targeting of Myc-Reprogrammed Cancer Cell Metabolism
- C.V. Dang
Cold Spring Harb Symp Quant Biol 2011 76: 369-374; Published in Advance September 29, 2011, doi:10.1101/sqb.2011.76.011296

Apoptosis and Autophagy

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Integration of Apoptosis and Metabolism
- C.H. Yi,
- H. Vakifahmetoglu-Norberg,
- and J. Yuan
Cold Spring Harb Symp Quant Biol 2011 76: 375-387; Published in Advance November 16, 2011, doi:10.1101/sqb.2011.76.010777
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Autophagy, Stress, and Cancer Metabolism: What Doesn't Kill You Makes You Stronger
- R. Mathew and
- E. White
Cold Spring Harb Symp Quant Biol 2011 76: 389-396; Published in Advance March 22, 2012, doi:10.1101/sqb.2012.76.011015
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Autophagy in Protein and Organelle Turnover
- N. Mizushima
Cold Spring Harb Symp Quant Biol 2011 76: 397-402; Published in Advance August 3, 2011, doi:10.1101/sqb.2011.76.011023
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Back to the Future: Molecular Biology Meets Metabolism
- Steven L. McKnight
Cold Spring Harb Symp Quant Biol 2011 76: 403-411; Published in Advance April 17, 2012, doi:10.1101/sqb.2012.76.013722

Author Index

Author Index
Cold Spring Harb Symp Quant Biol 2011 76: 413; doi:10.1101/sqb.2011.76.AI
- Full Text (PDF)

Subject Index

Subject Index
Cold Spring Harb Symp Quant Biol 2011 76: 414-422; doi:10.1101/sqb.2011.76.SI
- Full Text (PDF)

Metabolism and Disease vol. 76, 2011

Table of Contents

Front Matter

Front Matter

Introduction

Bioenergetic Origins of Complexity and Disease

Nuclear Receptors and AMPK: Resetting Metabolism

Rethinking the Regulation of Cellular Metabolism

Clocks and Rhythms

The Time of Metabolism: NAD+, SIRT1, and the Circadian Clock

The Mammalian Circadian Timing System: Synchronization of Peripheral Clocks

Circadian Epigenomic Remodeling and Hepatic Lipogenesis: Lessons from HDAC3

Estrogen-Related Receptor α, the Molecular Clock, and Transcriptional Control of Metabolic Outputs

Circadian Clocks in Fuel Harvesting and Energy Homeostasis

Life Span and Aging

Gamete Formation Resets the Aging Clock in Yeast

Sirtuins, Aging, and Metabolism

The Heat Shock Response: Systems Biology of Proteotoxic Stress in Aging and Disease

Skeletal Muscle Stem Cells: Effects of Aging and Metabolism on Muscle Regenerative Function

The C. elegans DAF-2 Insulin-Like Receptor is Abundantly Expressed in the Nervous System and Regulated by Nutritional Status

Regulation and Dysregulation of Metabolism

Surviving Starvation: Essential Role of the Ghrelin-Growth Hormone Axis

Transcriptional and Posttranscriptional Control of Cholesterol Homeostasis by Liver X Receptors

Roles of FGF19 in Liver Metabolism

A New Approach to an Old Problem: Synthetic Biology Tools for Human Disease and Metabolism

Signaling and Gene Regulation

Adenosine Monophosphate–Activated Protein Kinase: A Central Regulator of Metabolism with Roles in Diabetes, Cancer, and Viral Infection

Regulated Histone Methyltransferase and Demethylase Complexes in the Control of Genes by Nuclear Receptors

Transcriptional Control of Cardiac Fuel Metabolism and Mitochondrial Function

Metabolic Specialization of Mouse Embryonic Stem Cells

On Acetyl-CoA as a Gauge of Cellular Metabolic State

Metabolic Reprogramming

Nutrient-Dependent Acetylation Controls Basic Regulatory Metabolic Switches and Cellular Reprogramming

Control of Glycolysis through Regulation of PFK1: Old Friends and Recent Additions

ENTPD5, an Endoplasmic Reticulum UDPase, Alleviates ER Stress Induced by Protein Overloading in AKT-Activated Cancer Cells

MicroRNAs in Metabolism and Metabolic Diseases

Metabolomics in Drug Target Discovery

Fat, Intermediary Metabolism, and Exercise

Transcriptional Networks Controlling Adipocyte Differentiation

Adiponectin, Adiponectin Receptors, and Epigenetic Regulation of Adipogenesis

SIRT3 Regulates Mitochondrial Protein Acetylation and Intermediary Metabolism

Regulation of Male Fertility by Bone

Regulation of Glycolysis and Gluconeogenesis by Acetylation of PKM and PEPCK

NAD+ as a Signaling Molecule Modulating Metabolism

Metabolism and Cancer

Cancer Cell Metabolism

Extracellular Matrix Regulation of Metabolism and Implications for Tumorigenesis

Metabolic Pathway Alterations that Support Cell Proliferation

Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases

Regulation of Metabolism by Hypoxia-Inducible Factor 1

mRNA Translation and Energy Metabolism in Cancer: The Role of the MAPK and mTORC1 Pathways

Therapeutic Targeting of Myc-Reprogrammed Cancer Cell Metabolism

Apoptosis and Autophagy

Integration of Apoptosis and Metabolism

Autophagy, Stress, and Cancer Metabolism: What Doesn't Kill You Makes You Stronger

Autophagy in Protein and Organelle Turnover

Back to the Future: Molecular Biology Meets Metabolism

Author Index

Author Index

Subject Index

Subject Index

This Volume

Metabolism and Disease vol. 76, 2011

Latest Complete Volume

The Time of Metabolism: NAD⁺, SIRT1, and the Circadian Clock

NAD⁺ as a Signaling Molecule Modulating Metabolism