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Comment: limma technical repeat correction
by
Gordon Smyth
51k
I have never analysed SomaScan data, so I cannot make any specific recommendations about how to analyse such data. I have however analysed …
Answer: Using voom-transformed counts for unsupervised analyses (PCA, Random Forest, Ela
by
Gordon Smyth
51k
voom() does not transform the data to be homoscedastic. Quite the opposite, it computes precision weights that reflect the mean-variance tr…
Answer: Package needs internet access
by
James W. MacDonald
67k
It's going to need internet access. When you switch to NCBI seqlevels, you are calling this function ``` .fetch_chrom_sizes_from_UCSC_d…
Answer: List of DEGs belonging to an Agilent-single color microarray experiment using Li
by
Gordon Smyth
51k
The first coefficient in your linear model appears to be an intercept term. In this context, you should not be using `method="global"` beca…
Comment: Package needs internet access
by
firestar
▴ 20
Updated with more code.
Votes
Answer: Using voom-transformed counts for unsupervised analyses (PCA, Random Forest, Ela
Answer: Using voom-transformed counts for unsupervised analyses (PCA, Random Forest, Ela
Comment: Harmonizing Gene Annotations for Meta-Analysis of GSE68183 and GSE80178
Dotplot from enricher outputting very few genes
Answer: [How to construct a model.matrix ]
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