Flestolol
Изглед
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Nazivi | |
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IUPAC naziv
3[1-(Karbamoilamino)-2-metil-2-propanil]amino2-hidroksipropil 2-fluorobenzoat
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Identifikacija | |
3D model (Jmol)
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ChemSpider | |
KEGG[1] | |
UNII | |
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Svojstva | |
C15H22FN3O4 | |
Molarna masa | 327,36 g·mol−1 |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
Reference infokutije | |
Flestolol je kratkotrajni agonist beta adrenergijskog receptora.[4]
Sinteza
[уреди | уреди извор]![](http://upload.wikimedia.org/wikipedia/commons/thumb/0/0a/Flestolol_synthesis.svg/500px-Flestolol_synthesis.svg.png)
Acilacijom glicidola (2) hloridom kiseline 1 nastaje estar 3. Reakcija tog intermedijera sa aminom 4, dobijenog reakcijom 1,1-dimetiletilendiamina sa urejom, daje flestolol (5).
Reference
[уреди | уреди извор]- ^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ Quon, CY; Stampfli, HF (1993). „Biochemical characterization of flestolol esterase”. Research communications in chemical pathology and pharmacology. 81 (3): 309—22. PMID 8235065.
- ^ Kam, Sheung Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; O'Donnell, John P.; Stampfli, Herman F.; Sum, Check Y.; Anderson, William G. (1984). „[(Arylcarbonyl)oxy]propanolamines. 1. Novel .beta.-blockers with ultrashort duration of action”. Journal of Medicinal Chemistry. 27 (8): 1007. PMID 6146718. doi:10.1021/jm00374a013.