Aktivin i inhibin

Inhibin, beta B
Inhibin, beta B
Identifikatori
Simbol	INHBB
Alt. simboli	activin B
Entrez	3625
HUGO	6067
OMIM	147390
RefSeq	NM_002193
UniProt	P09529
Ostali podaci
Lokus	Hromozom 2 cen-q13

Inhibin, beta A
Inhibin, beta A
	The Activin dimer, from 2ARV.pdb
Identifikatori
Simbol	INHBA
Alt. simboli	activin A
Entrez	3624
HUGO	6066
OMIM	147290
RefSeq	NM_002192
UniProt	P08476
Ostali podaci
Lokus	Hromozom 7 p15-p13

Inhibin, alfa
Inhibin, alfa
Identifikatori
Simbol	INHA
Entrez	3623
HUGO	6065
OMIM	147380
RefSeq	NM_002191
UniProt	P05111
Ostali podaci
Lokus	Hromozom 2 q33-qter

Aktivin i inhibin su dva blisko srodna proteinska kompleksa koji imaju skoro potpuno suprotno biološko dejstvo. Aktivin pospešuje FSH biosintezu i sekreciju, i učestvuje u regulaciji menstrualnog ciklusa. Poznato je da vrši i niz drugih funkcija, uključujući njegovo učešće u proliferaciji, diferencijaciji, apoptozi,^[1] metabolizmu, homeostazi, imunskom responsu, zarastanju rana,^[2] i endokrinom sistemu. Nasuptrot tome inhibin umanjuje FSH sintezu i inhibira njegovu sekreciju.^[3]

Inhibin, beta C
Identifikatori
Simbol	INHBC
Alt. simboli	activin C
Entrez	3626
HUGO	6068
OMIM	601233
RefSeq	NM_005538
UniProt	P55103
Ostali podaci
Lokus	Hromozom 12 q13

Inhibin, beta E
Identifikatori
Simbol	INHBE
Alt. simboli	activin E
Entrez	83729
HUGO	24029
OMIM	612031
RefSeq	NM_031479
UniProt	P58166
Ostali podaci
Lokus	Hromozom 12 q13.2

Aktivin je dimer koji se sastoji od dve identične ili veoma slične beta podjedinice. Inhibin je takođe dimer. Njegova jedna komponenta je beta podjedinica koja je slična ili identična sa beta podjedinicom aktivina. Međutim, u kontrastu sa aktivinom, druga komponenta inhibinskog dimera je manje srodna sa alfa podjedinicom.^[4]^[5] Aktivin, inhibin i brojni drugi strukturno srodni proteini, poput antimilerijanskog hormona, koštanog morfogenetičkog proteina, i diferencijacionog faktora rasta pripadaju TGF-β proteinskog superfamiliji.^[6]

Reference

^ Chen YG, Wang Q, Lin SL, Chang CD, Chuang J, Chung J, Ying SY (2006). „Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis”. Exp. Biol. Med. (Maywood). 231 (5): 534—44. PMID 16636301. ^{[мртва веза]}
^ Sulyok S, Wankell M, Alzheimer C, Werner S (2004). „Activin: an important regulator of wound repair, fibrosis, and neuroprotection”. Mol. Cell. Endocrinol. 225 (1–2): 127—32. PMID 15451577. doi:10.1016/j.mce.2004.07.011.
^ van Zonneveld P, Scheffer G, Broekmans F, Blankenstein M, de Jong F, Looman C, Habbema J, te Velde E (2003). „Do cycle disturbances explain the age-related decline of female fertility? Cycle characteristics of women aged over 40 years compared with a reference population of young women”. Hum Reprod. 18 (3): 495—501. PMID 12615813. doi:10.1093/humrep/deg138.
^ Burger HG, Igarashi M (1988). „Inhibin: definition and nomenclature, including related substances”. The Journal of Clinical Endocrinology and Metabolism. 66 (4): 885—6. PMID 3346366.
^ Robertson DM, Burger HG, Fuller PJ (2004). „Inhibin/activin and ovarian cancer”. Endocrine-related Cancer. 11 (1): 35—49. PMID 15027884. doi:10.1677/erc.0.0110035.
^ Kingsley DM (1994). „The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms”. Genes & Development. 8 (2): 133—46. PMID 8299934. doi:10.1101/gad.8.2.133.

Spoljašnje veze

Activin у речнику еMedicine
Activin на US National Library of Medicine Medical Subject Headings (MeSH)
Inhibin на US National Library of Medicine Medical Subject Headings (MeSH)
Grusch M, Kreidl E (1. 8. 2008). „Activin and follistatin in liver biology and hepatocellular carcinoma”. SciTopics. Elsevier. Архивирано из оригинала 9. 12. 2008. г. Приступљено 24. 12. 2008.

[pmid16636301-1] Chen YG, Wang Q, Lin SL, Chang CD, Chuang J, Chung J, Ying SY (2006). „Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis”. Exp. Biol. Med. (Maywood). 231 (5): 534—44. PMID 16636301. ^{[мртва веза]}

[pmid15451577-2] Sulyok S, Wankell M, Alzheimer C, Werner S (2004). „Activin: an important regulator of wound repair, fibrosis, and neuroprotection”. Mol. Cell. Endocrinol. 225 (1–2): 127—32. PMID 15451577. doi:10.1016/j.mce.2004.07.011.

[3] van Zonneveld P, Scheffer G, Broekmans F, Blankenstein M, de Jong F, Looman C, Habbema J, te Velde E (2003). „Do cycle disturbances explain the age-related decline of female fertility? Cycle characteristics of women aged over 40 years compared with a reference population of young women”. Hum Reprod. 18 (3): 495—501. PMID 12615813. doi:10.1093/humrep/deg138.

[pmid3346366-4] Burger HG, Igarashi M (1988). „Inhibin: definition and nomenclature, including related substances”. The Journal of Clinical Endocrinology and Metabolism. 66 (4): 885—6. PMID 3346366.

[pmid15027884-5] Robertson DM, Burger HG, Fuller PJ (2004). „Inhibin/activin and ovarian cancer”. Endocrine-related Cancer. 11 (1): 35—49. PMID 15027884. doi:10.1677/erc.0.0110035.

[pmid8299934-6] Kingsley DM (1994). „The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms”. Genes & Development. 8 (2): 133—46. PMID 8299934. doi:10.1101/gad.8.2.133.

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