5-Metoksitriptamin

5-Metoksitriptamin
IUPAC ime
	2-(5-Methoxy-1H-indol-3-yl)ethanamine
Klinički podaci
Prodajno ime	Mexamine; Meksamin
Identifikatori
CAS broj	608-07-1
PubChem	CID 1833
IUPHAR/BPS	107
ChemSpider	1767
KEGG	C05659
ChEMBL	CHEMBL8165
Hemijski podaci
Formula	C11H14N2O
Molarna masa	190.242 g/mol
	SMILES O(c1cc2c(cc1)ncc2CCN)C; ;
	InChI InChI=1S/C11H14N2O/c1-14-9-2-3-11-10(6—9)8(4-5-12)7-13-11/h2-3,6-7,13H,4-5,12H2,1H3 ; Key:JTEJPPKMYBDEMY-UHFFFAOYSA-N ;

5-Metoksitriptamin (5-MT, meksamin) je derivat triptamina. On je blisko srodan neurotransmiterima serotoninu i melatoninu. Za 5-MT je pokazano da se prirodno javlja u telu u niskim nivoima.^[1] On je proizvod dekarboksilacije melatonina u epifizi.^[1]

5-MT deluje kao pun agonist 5-HT₁, 5-HT₂, 5-HT₄, 5-HT₆, i 5-HT₇ receptora.^[2]^[3]^[4]^[5]^[6]^[7]^[8] On nema afinitet za 5-HT₃ receptor. Njegov afinitet za 5-HT_1E receptor je veoma slab u poređenju sa drugim 5-HT₁ receptorima.^[5]^[9]

Vidi još

Референце

^ ^а ^б Galzin AM, Eon MT, Esnaud H, Lee CR, Pévet P, Langer SZ (1988). „Day-night rhythm of 5-methoxytryptamine biosynthesis in the pineal gland of the golden hamster (Mesocricetus auratus).”. J Endocrinol. 118 (3): 389—397. PMID 2460575. doi:10.1677/joe.0.1180389.
^ Wu PH, Gurevich N, Carlen PL (1988). „Serotonin-1A receptor activation in hippocampal CA1 neurons by 8-hydroxy-2-(di-n-propylamino)tetralin, 5-methoxytryptamine and 5-hydroxytryptamine.”. Neurosci Lett. 86 (1): 72—76. PMID 2966313. doi:10.1016/0304-3940(88)90185-1.
^ Yamada J, Sugimoto Y, Yoshikawa T, Horisaka K (1997). „Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor.”. Eur J Pharmacol. 323 (2-3): 235—240. PMID 9128844. doi:10.1016/S0014-2999(97)00029-0.
^ Amemiya N, Hatta S, Takemura H, Ohshika H (1996). „Characterization of the contractile response induced by 5-methoxytryptamine in rat stomach fundus strips.”. Eur J Pharmacol. 318 (2-3): 403—409. PMID 9016931. doi:10.1016/S0014-2999(96)00777-7.
^ ^а ^б Craig DA, Eglen RM, Walsh LK, Perkins LA, Whiting RL, Clarke DE (1990). „5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum.”. Naunyn Schmiedebergs Arch Pharmacol. 342 (1): 9—16. PMID 2402303.
^ Boess FG, Monsma FJ Jr, Carolo C, Meyer V, Rudler A, Zwingelstein C, Sleight AJ (1997). „Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells.”. Neuropharmacology. 36 (4-5): 713—720. PMID 9225298. doi:10.1016/S0028-3908(97)00019-1.
^ Hemedah M, Coupar IM, Mitchelson FJ (1999). „[3H]-Mesulergine labels 5-HT7 sites in rat brain and guinea-pig ileum but not rat jejunum.”. Br J Pharmacol. 126 (1): 179—188. PMC 1565797  . PMID 10051134. doi:10.1038/sj.bjp.0702293.
^ Glennon RA, Dukat M, Westkaemper RB (1. 1. 2000). „Serotonin Receptor Subtypes and Ligands”. American College of Neurophyscopharmacology. Приступљено 11. 4. 2008.
^ Roth, Brian (2006). The serotonin receptors. Humana Press. стр. 133. ISBN 978-1-58829-568-2.

Литература

Roth, Brian (2006). The serotonin receptors. Humana Press. стр. 133. ISBN 978-1-58829-568-2.

[pmid2460575-1] а ^б Galzin AM, Eon MT, Esnaud H, Lee CR, Pévet P, Langer SZ (1988). „Day-night rhythm of 5-methoxytryptamine biosynthesis in the pineal gland of the golden hamster (Mesocricetus auratus).”. J Endocrinol. 118 (3): 389—397. PMID 2460575. doi:10.1677/joe.0.1180389.

[pmid2966313-2] Wu PH, Gurevich N, Carlen PL (1988). „Serotonin-1A receptor activation in hippocampal CA1 neurons by 8-hydroxy-2-(di-n-propylamino)tetralin, 5-methoxytryptamine and 5-hydroxytryptamine.”. Neurosci Lett. 86 (1): 72—76. PMID 2966313. doi:10.1016/0304-3940(88)90185-1.

[pmid9128844-3] Yamada J, Sugimoto Y, Yoshikawa T, Horisaka K (1997). „Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor.”. Eur J Pharmacol. 323 (2-3): 235—240. PMID 9128844. doi:10.1016/S0014-2999(97)00029-0.

[pmid9016931-4] Amemiya N, Hatta S, Takemura H, Ohshika H (1996). „Characterization of the contractile response induced by 5-methoxytryptamine in rat stomach fundus strips.”. Eur J Pharmacol. 318 (2-3): 403—409. PMID 9016931. doi:10.1016/S0014-2999(96)00777-7.

[pmid2402303-5] а ^б Craig DA, Eglen RM, Walsh LK, Perkins LA, Whiting RL, Clarke DE (1990). „5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum.”. Naunyn Schmiedebergs Arch Pharmacol. 342 (1): 9—16. PMID 2402303.

[pmid9225298-6] Boess FG, Monsma FJ Jr, Carolo C, Meyer V, Rudler A, Zwingelstein C, Sleight AJ (1997). „Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells.”. Neuropharmacology. 36 (4-5): 713—720. PMID 9225298. doi:10.1016/S0028-3908(97)00019-1.

[pmid10051134-7] Hemedah M, Coupar IM, Mitchelson FJ (1999). „[3H]-Mesulergine labels 5-HT7 sites in rat brain and guinea-pig ileum but not rat jejunum.”. Br J Pharmacol. 126 (1): 179—188. PMC 1565797  . PMID 10051134. doi:10.1038/sj.bjp.0702293.

[urlSerotonin_Receptor_Subtypes_and_Ligands-8] Glennon RA, Dukat M, Westkaemper RB (1. 1. 2000). „Serotonin Receptor Subtypes and Ligands”. American College of Neurophyscopharmacology. Приступљено 11. 4. 2008.

[bookThe_Serotonin_Receptors-9] Roth, Brian (2006). The serotonin receptors. Humana Press. стр. 133. ISBN 978-1-58829-568-2.

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