XPB — разлика између измена

-{'''XPB'''}- (-{Xeroderma Pigmentosum B}-) je [[Adenozin trifosfat|ATP]] zavisna ljudska DNK [[helikaza]] koja je deo kompleksa [[Transkripcioni faktor II H|TFIIH]] [[Transkripcioni faktor|transkripcionog faktora]]. 3D struktura -{XPB}- homologa je kristalografski.<ref>{{cite journal |authorvauthors=Fan L, Arvai A, Cooper P, Iwai S, Hanaoka F, Tainer J |title=Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair |journal=Mol Cell |volume=22 |issue=1 |pages=27–37 |year=2006 |pmid=16600867 |doi=10.1016/j.molcel.2006.02.017|pages=27–37}}</ref>

== Funkcija ==

-{XPB}- formira [[Protein-protein interakcija|interakcije]] sa [[XPC (gen)|-{XPC}-]],<ref name="pmid10734143">{{cite journal |last=Yokoi |first=M |authorlinkdisplay-authors= |coauthors=Masutani C, Maekawa T, Sugasawa K, Ohkuma Y, Hanaoka Fetal |year=2000|month=March |title=The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA |journal=J. Biol. Chem. |volume=275 |issue=13 |pages=9870–5 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10734143 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.275.13.9870 |pages=9870–5}}</ref> [[BCR gen|-{BCR}- genom]],<ref name="pmid9874796">{{cite journal |last=Takeda |first=N |authorlinkdisplay-authors= |coauthors=Shibuya M, Maru Yetal |year=1999|month=January |title=The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein |journal= Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue=1 |pages=203–7 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 9874796 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.96.1.203 |pmc=15117 |pages=203–7}}</ref> -{[[ERCC2]]}-,<ref name="pmid15220921">{{cite journal |last=Giglia-Mari |first=Giuseppina |authorlinkdisplay-authors= |coauthors=Coin Frederic, Ranish Jeffrey A, Hoogstraten Deborah, Theil Arjan, Wijgers Nils, Jaspers Nicolaas G J, Raams Anja, Argentini Manuela, van der Spek P J, Botta Elena, Stefanini Miria, Egly Jean-Marc, Aebersold Ruedi, Hoeijmakers Jan H J, Vermeulen Wimetal |year=2004|month=July |title=A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A |journal=Nat. Genet. |volume=36 |issue=7 |pages=714–9 |publisher= |location = United States| issn = 1061-4036| pmid = 15220921 |doi = 10.1038/ng1387 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |unused_data=DUPLICATE DATA: pmid = 15226750 }}</ref><ref name="pmid9118947">{{cite journal |last=Marinoni |first=J C |authorlinkdisplay-authors= |coauthors=Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez D M, Hoeijmakers J H, Egly J M etal|year=1997|month=March |title=Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH |journal=EMBO J. |volume=16 |issue=5 |pages=1093–102 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 9118947 |doi = 10.1093/emboj/16.5.1093 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1169708 |pages=714–9}}</ref><ref name="pmid8152490">{{cite journal |last=Drapkin |first=R |authorlinkdisplay-authors= |coauthors=Reardon J T, Ansari A, Huang J C, Zawel L, Ahn K, Sancar A, Reinberg Detal |year=1994|month=April |title=Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II |journal= Nature |volume=368 |issue=6473 |pages=769–72 |publisher= |location = ENGLAND| issn = 0028-0836| pmid = 8152490 |doi = 10.1038/368769a0 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pages=769–72}}</ref><ref name="pmid8652557">{{cite journal |last=Iyer |first=N |authorlinkdisplay-authors= |coauthors=Reagan M S, Wu K J, Canagarajah B, Friedberg E Cetal |year=1996|month=February |title=Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein |journal=Biochemistry |volume=35 |issue=7 |pages=2157–67 |publisher= |location = UNITED STATES| issn = 0006-2960| pmid = 8652557 |doi = 10.1021/bi9524124 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pages=2157–67}}</ref> -{[[P53]]}-,<ref name="pmid7663514">{{cite journal |last=Wang |first=X W |authorlinkdisplay-authors= |coauthors=Yeh H, Schaeffer L, Roy R, Moncollin V, Egly J M, Wang Z, Freidberg E C, Evans M K, Taffe B G etal|year=1995|month=June |title=p53 modulation of TFIIH-associated nucleotide excision repair activity |journal=Nat. Genet. |volume=10 |issue=2 |pages=188–95 |publisher= |location = UNITED STATES| issn = 1061-4036| pmid = 7663514 |doi = 10.1038/ng0695-188 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pages=188–95}}</ref> -{[[GTF2H2]]}-,<ref name="pmid15220921"/><ref name="pmid9118947"/> -{[[GTF2H1]]}-,<ref name="pmid15220921"/><ref name="pmid9118947"/><ref name="pmid9130708">{{cite journal |last=Rossignol |first=M |authorlinkdisplay-authors= |coauthors=Kolb-Cheynel I, Egly J Metal |year=1997|month=April |title=Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH |journal=EMBO J. |volume=16 |issue=7 |pages=1628–37 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 9130708 |doi = 10.1093/emboj/16.7.1628 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1169767 |pages=1628–37}}</ref> -{[[GTF2H5]]}-,<ref name="pmid15220921"/> [[Ciklin zavisna kinaza 7|ciklin zavisnom kinazom]],<ref name="pmid15220921"/><ref name="pmid9130708"/><ref name="pmid8521393">{{cite journal |last=Yee |first=A |authorlinkdisplay-authors= |coauthors=Nichols M A, Wu L, Hall F L, Kobayashi R, Xiong Yetal |year=1995|month=December |title=Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor |journal=Cancer Res. |volume=55 |issue=24 |pages=6058–62 |publisher= |location = UNITED STATES| issn = 0008-5472| pmid = 8521393 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pages=6058–62}}</ref> -{[[PSMC5]]}-<ref name="pmid9173976">{{cite journal |last=Weeda |first=G |authorlinkdisplay-authors= |coauthors=Rossignol M, Fraser R A, Winkler G S, Vermeulen W, van 't Veer L J, Ma L, Hoeijmakers J H, Egly J Metal |year=1997|month=June |title=The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor |journal=Nucleic Acids Res. |volume=25 |issue=12 |pages=2274–83 |publisher= |location = ENGLAND| issn = 0305-1048| pmid = 9173976 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1093/nar/25.12.2274 |pmc=146752 |pages=2274–83}}</ref> i -{[[GTF2H4]]}-.<ref name="pmid15220921"/><ref name="pmid9118947"/>

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== Spoljašnje veze ==