Express vs. FastAPI vs. MicroPython vs. PydanticAI Comparison Chart

FastAPI is a modern, fast (high-performance), web framework for building APIs with Python 3.7+ based on standard Python type hints. Fast: Very high performance, on par with NodeJS and Go (thanks to Starlette and Pydantic). One of the fastest Python frameworks available. Minimize code duplication, multiple features from each parameter declaration.

PydanticAI is a Python-based agent framework designed to simplify the development of production-grade applications using generative AI. Built by the team behind Pydantic, the framework integrates seamlessly with popular AI models such as OpenAI, Anthropic, Gemini, and others. It offers type-safe design, real-time debugging, and performance monitoring through Pydantic Logfire. PydanticAI also provides structured responses by leveraging Pydantic to validate model outputs, ensuring consistency. The framework includes a dependency injection system to support iterative development and testing, as well as the ability to stream LLM outputs for rapid validation. It is ideal for AI-driven projects that require flexible and efficient agent composition using standard Python best practices. We built PydanticAI with one simple aim: to bring that FastAPI feeling to GenAI app development.