Cython vs. D vs. Vyper vs. python-sql Comparison Chart

Cython is an optimizing static compiler for both the Python programming language and the extended Cython programming language (based on Pyrex). It makes writing C extensions for Python as easy as Python itself. Cython gives you the combined power of Python and C to let you write Python code that calls back and forth from and to C or C++ code natively at any point. Easily tune readable Python code into plain C performance by adding static type declarations, also in Python syntax. Use combined source code level debugging to find bugs in your Python, Cython, and C code. Interact efficiently with large data sets, e.g. using multi-dimensional NumPy arrays. Quickly build your applications within the large, mature, and widely used CPython ecosystem. The Cython language is a superset of the Python language that additionally supports calling C functions and declaring C types on variables and class attributes.

Vyper is a contract-oriented, pythonic programming language that targets the Ethereum Virtual Machine (EVM). Security: It should be possible and natural to build secure smart-contracts in Vyper. Language and compiler simplicity: The language and the compiler implementation should strive to be simple. Auditability: Vyper code should be maximally human-readable. Furthermore, it should be maximally difficult to write misleading code. Simplicity for the reader is more important than simplicity for the writer, and simplicity for readers with low prior experience with Vyper (and low prior experience with programming in general) is particularly important.