Izvorni kod stranice Proteaza

'''Proteaza''' (''peptidaza'', ''proteinaza'') je [[enzim]] koji izvodi [[proteoliza|proteolizu]]. Proteaza započinje [[protein]]ski [[katabolizam]] [[hidroliza|hidrolizom]] [[peptidna veza|peptidnih veza]] koje povezuju [[aminokiselina|aminokiseline]] u [[polipeptid]]ne lance od kojih je formiran [[protein]].<ref name="VoetBiochemistry3rd">{{VoetBiochemistry3rd}}</ref><ref name="Branden_ProteinStructure2nd">{{Branden_ProteinStructure2nd}}</ref>

== Klasifikacija ==
=== Standard ===
Proteaze se dele u šest grupa:
* [[Serinska proteaza|Serinske proteaze]]
* [[Treoninska proteaza|Treoninske proteaze]]
* [[Cisteinska proteaza|Cisteinske proteaze]]
* [[Aspartatna proteaza|Aspartatne proteaze]]
* [[Metaloproteaza|Metaloproteaze]]
* [[Glutamatna proteaza|Glutamatne proteaze]]

[[Treonin]]ske i [[glutaminska kiselina|glutamatne]] proteaze nisu bile poznate do [[1995]] i [[2004]], respektivno. Mehanizam raskidanja [[peptidna veza|peptidne veze]] obuhvata korak u kome [[nukleofil]] napada peptidnu vezu. Nukleofil je bilo aminokiselina peptidaze ([[cistein]], [[serin]], [[treonin]]) ili molekul vode kod aspartat-, metalo- i glutamatne proteaze. Jedan način formiranja nukleofila je putem [[katalitička trijada|katalitičke trijade]], gde se [[histidin]]ski ostatak koristi za aktivaciju [[serin]]a, [[cistein]]a, ili [[treonin]]a.

== Reference ==
{{reflist|2}}

== Literatura ==
{{refbegin|2}}
* Barrett A.J., Rawlings ND, Woessner JF. ''The Handbook of Proteolytic Enzymes'', 2nd ed. Academic Press, 2003. {{ISBN|0-12-079610-4}}.
* Hedstrom L. ''Serine Protease Mechanism and Specificity.'' Chem Rev 2002;102:4501-4523.
* Southan C. ''A genomic perspective on human proteases as drug targets.'' Drug Discov Today 2001;6:681-688.
* Hooper NM. ''Proteases in Biology and Medicine''. London: Portland Press, 2002. {{ISBN|1-85578-147-6}}.
* Puente XS, Sanchez LM, Overall CM, Lopez-Otin C. ''Human and Mouse Proteases: a Comparative Genomic Approach.'' Nat Rev Genet 2003;4:544-558.
* Ross J, Jiang H, Kanost MR, Wang Y. ''Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships.'' Gene 2003;304:117-31.
* Puente XS, Lopez-Otin C. ''A Genomic Analysis of Rat Proteases and Protease Inhibitors.'' Genome Biol 2004;14:609-622.
* Lucía Feijoo-Siota, Tomás G. Villa ''Native and Biotechnologically Engineered Plant Proteases with Industrial Applications.'' Food and Bioprocess Technology 2010.
{{Refend}}

== Spoljašnje veze ==
* [http://www.protease.org/ Međunarodno udruženje za proteolizu]
* [http://merops.sanger.ac.uk/ Baza podataka peptidaza] {{Webarchive|url=https://web.archive.org/web/20061114180435/http://merops.sanger.ac.uk/ |date=2006-11-14 }}
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{{Proteaze}}

{{Enzimi}}

[[Kategorija:Peptidaze]]