Farmakokinetika

Farmakokinetika, skraćeno PK, (od starogrčkog pharmakon "lek" i kinetikos "vezano za kretanje") je grana farmakologije koja se bavi izučavanjem promena supstanci doziranih u žive organizme. Supstance od interesa su farmaceutski agensi, hormoni, nutrijenti, i toksini. Ona pokužava da otkrije sudbinu leka od momenta njegovog unosa do tačke u kojoj je kompletno eliminisan iz tela.

Farmakokinetika se može jednostavno definisati kao to što telo radi leku, dok je farmakodinamika usredsređena na to što lek radi telu.^[1]

Farmakokinetika opisuje kako telo deluje na specifični lek nakon doziranja putem mehanizama apsorpcije i distribucije, kao i hemijske promene supstane u telu (e.g. posredstvom metaboličkih enzima kao što su enzimi citohrom P450 ili glukuronoziltransferaza), i efekte i puteve izlučivanja metabolita leka.^[2] Farmakokinetička svojstva leka mogu da budu uslovljena faktorima poput mesta administriranja i doze leka. Ti faktori mogu da utiču na brzinu apsorpcije.^[3] Farmakokinetika se često studira zajedno sa farmakodinamikom.

Reference

↑ Benet LZ (1984). „Pharmacokinetics: Basic Principles and Its Use as a Tool in Drug Metabolism”. u: Horning MG, Mitchell J. Drug metabolism and drug toxicity. New York: Raven Press. ISBN 0-89004-997-1. Arhivirano iz originala na datum 2013-10-20. Pristupljeno 2014-03-11.
↑ Pharmacokinetics. (2006). In Mosby's Dictionary of Medicine, Nursing, & Health Professions. Philadelphia, PA: Elsevier Health Sciences. Retrieved December 11, 2008, from http://www.credoreference.com/entry/6686418
↑ Kathleen Knights; Bronwen Bryant (2002). Pharmacology for Health Professionals. Amsterdam: Elsevier. ISBN 0-7295-3664-5.

Literatura

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Kathleen Knights; Bronwen Bryant (2002). Pharmacology for Health Professionals. Amsterdam: Elsevier. ISBN 0-7295-3664-5.
Alberts et al., Introducción a la Biología Celular, pág. 375-376, 2ª edición, Ed. Médica Panamericana
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Armijo JA. 2003. Farmacocinética: Absorción, Distribución y Eliminación de los Fármacos. En: Flórez J, Armijo JA, Mediavilla A, Farmacología Humana, 4ta edición. Masson. Barcelona. pp: 51-79.
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Povezano

Spoljašnje veze

[1] Benet LZ (1984). „Pharmacokinetics: Basic Principles and Its Use as a Tool in Drug Metabolism”. u: Horning MG, Mitchell J. Drug metabolism and drug toxicity. New York: Raven Press. ISBN 0-89004-997-1. Arhivirano iz originala na datum 2013-10-20. Pristupljeno 2014-03-11.

[2] Pharmacokinetics. (2006). In Mosby's Dictionary of Medicine, Nursing, & Health Professions. Philadelphia, PA: Elsevier Health Sciences. Retrieved December 11, 2008, from http://www.credoreference.com/entry/6686418

[3] Kathleen Knights; Bronwen Bryant (2002). Pharmacology for Health Professionals. Amsterdam: Elsevier. ISBN 0-7295-3664-5.

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