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Trends in Medical Research

Year: 2012 | Volume: 7 | Issue: 2 | Page No.: 34-42
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Authors

A. Kumari

V. Kumar

S.K. Yadav

Keywords

Review Article

Nanotechnology: A Tool to Enhance Therapeutic Values of Natural Plant Products

A. Kumari
Plant Metabolic Engineering and Nanobiology Laboratory, Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur-176061, India
V. Kumar
Plant Metabolic Engineering and Nanobiology Laboratory, Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur-176061, India
S.K. Yadav
Plant Metabolic Engineering and Nanobiology Laboratory, Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur-176061, India
Natural product isolation and extraction is full of many technical hitches. In spite of that plant origin natural products have occupied lead positions as drugs in current pharmacopoeia. In this article, problems in natural product drug development and the possibilities of their improvement through nanoformulations using nanotechnology have been reviewed. Known effects and no side effects have made natural products a powerful therapeutic solution to the organisms. But the delivery of plant origin therapeutic molecules as drugs is problematic due to poor solubility, poor permeability, low bioavailability, instability in biological milieu and extensive first pass metabolism. These limitations of plant origin drugs can be overcome by attaching or encapsulating them with suitable nanomaterials. Nanomaterials can significantly enhance the pharmacokinetics and therapeutic index of plant origin drugs. Targeted delivery and combination therapy can drastically improve the performance of plant origin drugs.
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