Просмотр кода страницы RFC1

{{GNF_Protein_box
 | Name = Фактор репликации C (активатор 1) 1, 145kDa
 | image = Protein_RFC1_PDB_2EBU.png
 | image_source = Представлено на основе [[Protein_Data_Bank | PDB]] {{PDB2|2EBU}}.
 | PDB = {{PDB2|2EBU}}, {{PDB2|2K6G}}, {{PDB2|2K7F}}
 | HGNCid = 9969
 | MGIid = 97891
 | Symbol = RFC1
 | AltSymbols =; A1; MHCBFB; PO-GA; RECC1; RFC; RFC140
 | IUPHAR = 
 | ChEMBL = 
 | OMIM = 102579
 | ECnumber = 
 | Homologene = 2187
 | GeneAtlas_image1 = PBB_GE_RFC1_208021_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_RFC1_209085_x_at_tn.png
 | GeneAtlas_image3 = 
 | Protein_domain_image = 
 | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003689 |text = DNA clamp loader activity}} {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008047 |text = enzyme activator activity}} {{GNF_GO|id=GO:0019904 |text = protein domain specific binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005663 |text = DNA replication factor C complex}} {{GNF_GO|id=GO:0005730 |text = nucleolus}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0030054 |text = cell junction}} {{GNF_GO|id=GO:0070062 |text = extracellular vesicular exosome}}
 | Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0000278 |text = mitotic cell cycle}} {{GNF_GO|id=GO:0000722 |text = telomere maintenance via recombination}} {{GNF_GO|id=GO:0000723 |text = telomere maintenance}} {{GNF_GO|id=GO:0006200 |text = ATP catabolic process}} {{GNF_GO|id=GO:0006261 |text = DNA-dependent DNA replication}} {{GNF_GO|id=GO:0006271 |text = DNA strand elongation involved in DNA replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006283 |text = transcription-coupled nucleotide-excision repair}} {{GNF_GO|id=GO:0006289 |text = nucleotide-excision repair}} {{GNF_GO|id=GO:0006297 |text = nucleotide-excision repair, DNA gap filling}} {{GNF_GO|id=GO:0006351 |text = transcription, DNA-templated}} {{GNF_GO|id=GO:0007004 |text = telomere maintenance via telomerase}} {{GNF_GO|id=GO:0032201 |text = telomere maintenance via semi-conservative replication}} {{GNF_GO|id=GO:0043085 |text = positive regulation of catalytic activity}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-templated}}
 | Hs_EntrezGene = 5981
 | Hs_Ensembl = ENSG00000035928
 | Hs_RefseqmRNA = NM_001204747
 | Hs_RefseqProtein = NP_001191676
 | Hs_GenLoc_db = hg19
 | Hs_GenLoc_chr = 4
 | Hs_GenLoc_start = 39289076
 | Hs_GenLoc_end = 39367995
 | Hs_Uniprot = P35251
 | Mm_EntrezGene = 19687
 | Mm_Ensembl = ENSMUSG00000029191
 | Mm_RefseqmRNA = NM_011258
 | Mm_RefseqProtein = NP_035388
 | Mm_GenLoc_db = mm10
 | Mm_GenLoc_chr = 5
 | Mm_GenLoc_start = 65261852
 | Mm_GenLoc_end = 65335670
 | Mm_Uniprot = P35601
 | path = PBB/5981
}}

''' Фактор репликации С субъединица 1 ''' — [[белок]], кодируемый у человека [[ген]]ом '' RFC1 ''. <ref name="pmid8114700">{{статья |заглавие=Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans |ссылка=https://archive.org/details/sim_molecular-and-cellular-biology_1994-03_14_3/page/1626 |издание=[[Molecular and Cellular Biology]] |том=14 |номер=3 |страницы=1626—1634 |pmid=8114700 |pmc=358521 |язык=en |тип=journal |автор=Luckow B., Bunz F., Stillman B., Lichter P., Schütz G. |месяц=3 |год=1994}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5981| accessdate = }}</ref>

== Функция ==
[[Белок]], кодируемый этим [[ген]]ом является большой субъединицей фактора репликации С, который является субъединицей пяти аксессуарных белков [[ДНК-полимераза|ДНК-полимеразы]]. Фактор репликации С является ДНК-зависимой [[АТФаза|АТФазой]], что требуется для [[Эукариоты|эукариотической]] [[Репликация ДНК|репликации]] и [[Репарация ДНК|репарации]] [[ДНК]]. Белок действует в качестве активатора ДНК-полимераз, связывается с 3'-концами праймеров, а также способствует скоординированному синтезу обеих нитей. Он также может играть определенную роль в стабильности [[Теломеры|теломеров]]. <ref name="entrez" />

== Взаимодействия ==
RFC1, как было выявлено, [[Белок-белковые взаимодействия|взаимодействует]] с:

* [[BRD4]], <ref name = pmid12192049>{{статья |заглавие=A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase |ссылка=https://archive.org/details/sim_molecular-and-cellular-biology_2002-09_22_18/page/6509 |издание=[[Molecular and Cellular Biology]] |том=22 |номер=18 |страницы=6509—6520 |pmid=12192049 |pmc=135621 |doi=10.1128/mcb.22.18.6509-6520.2002 |язык=en |тип=journal |автор=Maruyama T., Farina A., Dey A., Cheong J., Bermudez V.P., Tamura T., Sciortino S., Shuman J., Hurwitz J., Ozato K. |месяц=9 |год=2002}}</ref>
* [[HDAC1]], <ref name = pmid12045192>{{статья |заглавие=The large subunit of replication factor C interacts with the histone deacetylase, HDAC1 |издание=[[Journal of Biological Chemistry]] |том=277 |номер=33 |страницы=29550—29554 |pmid=12045192 |doi=10.1074/jbc.M200513200 |язык=en |тип=journal |автор=Anderson L.A., Perkins N.D. |месяц=8 |год=2002}}</ref>
* [[PCNA]], <ref name = pmid12192049/><ref name = pmid8861969>{{статья |заглавие=A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells |издание=[[The EMBO Journal]] |том=15 |номер=16 |страницы=4423—4433 |pmid=8861969 |pmc=452166 |язык=en |тип=journal |автор=Fotedar R., Mossi R., Fitzgerald P., Rousselle T., Maga G., Brickner H., Messier H., Kasibhatla S., Hübscher U., Fotedar A. |месяц=8 |год=1996}}</ref><ref name = pmid8999859>{{статья |заглавие=Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen |издание=[[Journal of Biological Chemistry]] |том=272 |номер=3 |страницы=1769—1776 |pmid=8999859 |doi=10.1074/jbc.272.3.1769 |язык=en |тип=journal |автор=Mossi R., Jónsson Z.O., Allen B.L., Hardin S.H., Hübscher U. |месяц=1 |год=1997}}</ref><ref name = pmid10353443>{{статья |заглавие=The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins |издание={{Нп3|Journal of Molecular Medicine}} |том=77 |номер=4 |страницы=386—392 |pmid=10353443 |doi=10.1007/s001090050365 |язык=en |тип=journal |автор=van der Kuip H., Carius B., Haque S.J., Williams B.R., Huber C., Fischer T. |месяц=4 |год=1999}}</ref><ref name = pmid12171929>{{статья |заглавие=A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein |издание=[[Journal of Biological Chemistry]] |том=277 |номер=43 |страницы=40362—40367 |pmid=12171929 |doi=10.1074/jbc.M206194200 |язык=en |тип=journal |автор=Ohta S., Shiomi Y., Sugimoto K., Obuse C., Tsurimoto T. |месяц=10 |год=2002}}</ref>
* [[РЕЛА]] <ref name = pmid12509469>{{статья |заглавие=Regulation of RelA (p65) function by the large subunit of replication factor C |ссылка=https://archive.org/details/sim_molecular-and-cellular-biology_2003-01_23_2/page/721 |издание=[[Molecular and Cellular Biology]] |том=23 |номер=2 |страницы=721—732 |pmid=12509469 |pmc=151544 |doi=10.1128/mcb.23.2.721-732.2003 |язык=en |тип=journal |автор=Anderson L.A., Perkins N.D. |месяц=1 |год=2003}}</ref> и
* [[RFC3]]. <ref name = pmid9488738>{{статья |заглавие=Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity |издание=[[Journal of Biological Chemistry]] |том=273 |номер=10 |страницы=5979—5987 |pmid=9488738 |doi=10.1074/jbc.273.10.5979 |язык=en |тип=journal |автор=Ellison V., Stillman B. |месяц=3 |год=1998}}</ref><ref name = pmid8692848>{{статья |заглавие=In vitro reconstitution of human replication factor C from its five subunits |издание=[[Proceedings of the National Academy of Sciences|Proceedings of the National Academy of Sciences of the United States of America]] |том=93 |номер=13 |страницы=6521—6526 |pmid=8692848 |pmc=39056 |doi=10.1073/pnas.93.13.6521 |язык=en |тип=journal |автор=Uhlmann F., Cai J., Flores-Rozas H., Dean F.B., Finkelstein J., O'Donnell M., Hurwitz J. |месяц=6 |год=1996}}</ref><ref name = pmid18245774>{{статья |заглавие=DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex |издание=[[Journal of Biological Chemistry]] |том=283 |номер=14 |страницы=9071—9079 |pmid=18245774 |pmc=2431014 |doi=10.1074/jbc.M709835200 |язык=en |тип=journal |автор=Tomida J., Masuda Y., Hiroaki H., Ishikawa T., Song I., Tsurimoto T., Tateishi S., Shiomi T., Kamei Y., Kim J., Kamiya K., Vaziri C., Ohmori H., Todo T. |месяц=4 |год=2008}}</ref>

== Примечания ==
{{Примечания}}

== Литература ==
{{refbegin | 2}}
*{{статья |заглавие=The human DNA-binding protein, PO-GA, is homologous to the large subunit of mouse replication factor C: regulation by alternate 3' processing of mRNA |издание={{Нп3|Gene (журнал)|Gene||Gene (journal)}} |том=145 |номер=2 |страницы=261—265 |pmid=7914507 |doi=10.1016/0378-1119(94)90017-5 |язык=en |тип=journal |автор=Lu Y., Riegel A.T. |год=1994 |издательство=[[Elsevier]] }}
*{{статья |заглавие=cDNAs encoding the large subunit of human replication factor C |издание=[[Proceedings of the National Academy of Sciences|Proceedings of the National Academy of Sciences of the United States of America]] |том=90 |номер=23 |страницы=11014—11018 |pmid=8248204 |pmc=47912 |doi=10.1073/pnas.90.23.11014 |язык=en |тип=journal |автор=Bunz F., Kobayashi R., Stillman B. |год=1994}}
*{{статья |заглавие=Cloning and expression of a novel human DNA binding protein, PO-GA |издание={{Нп3|Biochemical and Biophysical Research Communications}} |том=193 |номер=2 |страницы=779—786 |pmid=8512577 |doi=10.1006/bbrc.1993.1693 |язык=en |тип=journal |автор=Lu Y., Zeft A.S., Riegel A.T. |год=1993}}
*{{статья |заглавие=In vitro reconstitution of human replication factor C from its five subunits |издание=[[Proceedings of the National Academy of Sciences|Proceedings of the National Academy of Sciences of the United States of America]] |том=93 |номер=13 |страницы=6521—6526 |pmid=8692848 |pmc=39056 |doi=10.1073/pnas.93.13.6521 |язык=en |тип=journal |автор=Uhlmann F., Cai J., Flores-Rozas H., Dean F.B., Finkelstein J., O'Donnell M., Hurwitz J. |год=1996}}
*{{статья |заглавие=A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells |издание=[[The EMBO Journal]] |том=15 |номер=16 |страницы=4423—4433 |pmid=8861969 |pmc=452166 |язык=en |тип=journal |автор=Fotedar R., Mossi R., Fitzgerald P., Rousselle T., Maga G., Brickner H., Messier H., Kasibhatla S., Hübscher U., Fotedar A. |год=1996}}
*{{статья |заглавие=Replication factor C recognizes 5'-phosphate ends of telomeres |издание={{Нп3|Biochemical and Biophysical Research Communications}} |том=229 |номер=1 |страницы=310—315 |pmid=8954124 |doi=10.1006/bbrc.1996.1798 |язык=en |тип=journal |автор=Uchiumi F., Ohta T., Tanuma S. |год=1997}}
*{{статья |заглавие=Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen |издание=[[Journal of Biological Chemistry]] |том=272 |номер=3 |страницы=1769—1776 |pmid=8999859 |doi=10.1074/jbc.272.3.1769 |язык=en |тип=journal |автор=Mossi R., Jónsson Z.O., Allen B.L., Hardin S.H., Hübscher U. |год=1997}}
*{{статья |заглавие=The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme |ссылка=https://archive.org/details/sim_molecular-and-cellular-biology_1997-04_17_4/page/1817 |издание=[[Molecular and Cellular Biology]] |том=17 |номер=4 |страницы=1817—1823 |pmid=9121429 |pmc=232028 |язык=en |тип=journal |автор=Cujec T.P., Cho H., Maldonado E., Meyer J., Reinberg D., Peterlin B.M. |год=1997}}
*{{статья |заглавие=The large subunit of the DNA replication complex C (DSEB/RF-C140) cleaved and inactivated by caspase-3 (CPP32/YAMA) during Fas-induced apoptosis |издание=[[Journal of Biological Chemistry]] |том=272 |номер=31 |страницы=19562—19568 |pmid=9235961 |doi=10.1074/jbc.272.31.19562 |язык=en |тип=journal |автор=Ubeda M., Habener J.F. |год=1997}}
*{{статья |заглавие=The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis |издание=[[The EMBO Journal]] |том=16 |номер=21 |страницы=6346—6354 |pmid=9351817 |pmc=1170241 |doi=10.1093/emboj/16.21.6346 |язык=en |тип=journal |автор=Rhéaume E., Cohen L.Y., Uhlmann F., Lazure C., Alam A., Hurwitz J., Sékaly R.P., Denis F. |год=1998}}
*{{статья |заглавие=Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity |издание=[[Journal of Biological Chemistry]] |том=273 |номер=10 |страницы=5979—5987 |pmid=9488738 |doi=10.1074/jbc.273.10.5979 |язык=en |тип=journal |автор=Ellison V., Stillman B. |год=1998}}
*{{статья |заглавие=Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome |издание=Oncol. Res. |том=9 |номер=11—12 |страницы=629—639 |pmid=9563011 |язык=en |тип=journal |автор=Coll J.M., Hickey R.J., Cronkey E.A., Jiang H.Y., Schnaper L., Lee M.Y., Uitto L., Syvaoja J.E., Malkas L.H. |год=1998}}
*{{статья |заглавие=DNA recognition properties of the N-terminal DNA binding domain within the large subunit of replication factor C |издание=[[Nucleic Acids Research]] |том=26 |номер=17 |страницы=3877—3882 |pmid=9705493 |pmc=147807 |doi=10.1093/nar/26.17.3877 |язык=en |тип=journal |автор=Allen B.L., Uhlmann F., Gaur L.K., Mulder B.A., Posey K.L., Jones L.B., Hardin S.H. |год=1998}}
*{{статья |заглавие=The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins |издание={{Нп3|Journal of Molecular Medicine}} |том=77 |номер=4 |страницы=386—392 |pmid=10353443 |doi=10.1007/s001090050365 |язык=en |тип=journal |автор=van der Kuip H., Carius B., Haque S.J., Williams B.R., Huber C., Fischer T. |год=1999}}
*{{статья |заглавие=BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures |издание=[[Genes & Development]] |том=14 |номер=8 |страницы=927—939 |pmid=10783165 |pmc=316544 |язык=en |тип=journal |автор=Wang Y., Cortez D., Yazdi P., Neff N., Elledge S.J., Qin J. |год=2000}}
*{{статья |заглавие=SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint |издание=[[Genes & Development]] |том=16 |номер=5 |страницы=571—582 |pmid=11877377 |pmc=155356 |doi=10.1101/gad.970702 |язык=en |тип=journal |автор=Yazdi P.T., Wang Y., Zhao S., Patel N., Lee E.Y., Qin J. |год=2002}}
*{{статья |заглавие=The large subunit of replication factor C interacts with the histone deacetylase, HDAC1 |издание=[[Journal of Biological Chemistry]] |том=277 |номер=33 |страницы=29550—29554 |pmid=12045192 |doi=10.1074/jbc.M200513200 |язык=en |тип=journal |автор=Anderson L.A., Perkins N.D. |год=2002}}
*{{статья |заглавие=A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein |издание=[[Journal of Biological Chemistry]] |том=277 |номер=43 |страницы=40362—40367 |pmid=12171929 |doi=10.1074/jbc.M206194200 |язык=en |тип=journal |автор=Ohta S., Shiomi Y., Sugimoto K., Obuse C., Tsurimoto T. |год=2002}}
*{{статья |заглавие=A Mammalian Bromodomain Protein, Brd4, Interacts with Replication Factor C and Inhibits Progression to S Phase |ссылка=https://archive.org/details/sim_molecular-and-cellular-biology_2002-09_22_18/page/6509 |издание=[[Molecular and Cellular Biology]] |том=22 |номер=18 |страницы=6509—6520 |pmid=12192049 |pmc=135621 |doi=10.1128/MCB.22.18.6509-6520.2002 |язык=en |тип=journal |автор=Maruyama T., Farina A., Dey A., Cheong J., Bermudez V.P., Tamura T., Sciortino S., Shuman J., Hurwitz J., Ozato K. |год=2002}}
{{refend}}

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