(Q8083989)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41145

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41145&geneProductId=UniProtKB:P41145

1 reference

24 April 2018

G protein-coupled opioid receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

8 April 2019

Structure of the human κ-opioid receptor in complex with JDTic

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

protein binding

IPI

1 reference

8 April 2019

GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

dynorphin receptor activity

IPI

kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41145&geneProductId=UniProtKB:P41145

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41145&geneProductId=UniProtKB:P41145

16 July 2018

16 July 2018

kappa opioid receptors in human microglia downregulate human immunodeficiency virus 1 expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41145&geneProductId=UniProtKB:P41145

receptor serine/threonine kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

G protein-coupled receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

dynorphin receptor activity

kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

8 April 2019

8 April 2019

kappa opioid receptors in human microglia downregulate human immunodeficiency virus 1 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

peptide binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

cell component

axon terminus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

integral component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

8 April 2019

8 April 2019

Structure of the human κ-opioid receptor in complex with JDTic

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

perikaryon

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

1 reference

8 April 2019

synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

integral component of plasma membrane

kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41145&geneProductId=UniProtKB:P41145

16 July 2018

kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41145&geneProductId=UniProtKB:P41145

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41145&geneProductId=UniProtKB:P41145

neuronal cell body

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

dendrite

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

neuron projection

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41145&geneProductId=UniProtKB:P41145

1 reference

16 July 2018

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

1 reference

8 April 2019

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

1 reference

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

8 April 2019

integral component of synaptic vesicle membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

integral component of postsynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

integral component of presynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

integral component of plasma membrane

kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

8 April 2019

kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

positive regulation of p38MAPK cascade

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

response to cocaine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

negative regulation of luteinizing hormone secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

1 reference

8 April 2019

kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

sensory perception

1 reference

8 April 2019

kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

regulation of sensory perception of pain

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

eating behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

behavioral response to cocaine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

sensory perception of temperature stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

estrous cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

conditioned place preference

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

response to estrogen

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

response to insulin

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

response to morphine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

positive regulation of dopamine secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

G protein-coupled opioid receptor signaling pathway

1 reference

16 July 2018

kappa opioid receptors in human microglia downregulate human immunodeficiency virus 1 expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41145&geneProductId=UniProtKB:P41145

defense response to virus

1 reference

8 April 2019

kappa opioid receptors in human microglia downregulate human immunodeficiency virus 1 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

maternal behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

immune response

1 reference

8 April 2019

kappa opioid receptors in human microglia downregulate human immunodeficiency virus 1 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

response to acrylamide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

positive regulation of potassium ion transmembrane transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

sensory perception of pain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

response to radiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

response to ethanol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

neuropeptide signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

cellular response to lipopolysaccharide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

positive regulation of locomotion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

1 reference

8 April 2019

adenylate cyclase-inhibiting opioid receptor signaling pathway

1 reference

8 April 2019

Structure of the human κ-opioid receptor in complex with JDTic

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

chemical synaptic transmission

1 reference

8 April 2019

kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

G protein-coupled receptor signaling pathway

animal behaviour

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

1 reference

8 April 2019

positive regulation of eating behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

cellular response to glucose stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41145

G protein-coupled opioid receptor signaling pathway

physically interacts with

1 reference

8866

17 August 2016

1 reference

7081

17 August 2016

1 reference

7082

17 August 2016

1 reference

7221

17 August 2016

1 reference

1652

17 August 2016

1 reference

1646

17 August 2016

1 reference

1649

17 August 2016

1 reference

1663

17 August 2016

1 reference

1651

17 August 2016

1 reference

1666

17 August 2016

2 references

1656

English

17 August 2016

1655

17 August 2016

1 reference

1667

17 August 2016

1 reference

1643

17 August 2016

1 reference

7591

17 August 2016

1 reference

1647

17 August 2016

1 reference

1616

17 August 2016

1 reference

1624

17 August 2016

1 reference

1626

17 August 2016

1 reference

1605

17 August 2016

1 reference

1627

17 August 2016

1 reference

1629

17 August 2016

1 reference

1606

17 August 2016

1 reference

7471

17 August 2016

1 reference

1670

17 August 2016

1 reference

1617

17 August 2016

1 reference

7563

17 August 2016

1 reference

1628

17 August 2016

1 reference

1638

17 August 2016

1 reference

1639

17 August 2016

1 reference

1640

17 August 2016

1 reference

1641

17 August 2016

1 reference

1633

17 August 2016

1 reference

7362

English

17 August 2016

dezocine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1685

butorphanol

Partial agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL33986

codeine

agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL485

aticaprant

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1921847

cebranopadol

agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2364605

naltrexone hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201149

nalbuphine hydrochloride

agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201132

naloxone hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1718

Gene Atlas image

PBB GE OPRK1 207553 at fs.png
732 × 530; 12 KB

0 references

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41145

Identifiers

MeSH descriptor ID

D017473

subject named as

Receptors, Opioid, kappa

0 references

MeSH tree code

D12.776.543.750.695.620.400

0 references

D12.776.543.750.720.600.610.400

0 references

D12.776.543.750.750.555.610.400

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

20 March 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023