(Q79397666)

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22 December 2019

review article

1 reference

title

Targeting the Hedgehog pathway in cancer (English)

1 reference

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22 December 2019

1

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22 December 2019

author name string

Frederic J de Sauvage

series ordinal

2

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22 December 2019

publication date

1 December 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17139287%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

22 December 2019

published in

1 reference

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22 December 2019

volume

5

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22 December 2019

issue

12

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22 December 2019

page(s)

1026-1033

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Hedgehog signaling in animal development: paradigms and principles

22 December 2019

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Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

31 March 2020

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

31 March 2020

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Self-renewal and cancer of the gut: two sides of a coin.

31 March 2020

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Mutations affecting segment number and polarity in Drosophila

31 March 2020

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Transducing the hedgehog signal

31 March 2020

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Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

31 March 2020

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Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

31 March 2020

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Cilia and Hedgehog responsiveness in the mouse

31 March 2020

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Hedgehog signalling in the mouse requires intraflagellar transport proteins

31 March 2020

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Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

31 March 2020

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Vertebrate Smoothened functions at the primary cilium

31 March 2020

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Catching a Gli-mpse of Hedgehog

31 March 2020

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Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E.

31 March 2020

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The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors

31 March 2020

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Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.

31 March 2020

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Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

31 March 2020

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Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.

31 March 2020

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Sonic hedgehog controls stem cell behavior in the postnatal and adult brain

31 March 2020

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Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation

31 March 2020

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Schwann cell-derived desert hedgehog signals nerve sheath formation

31 March 2020

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Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths

31 March 2020

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Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy

31 March 2020

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Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

31 March 2020

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Human homolog of patched, a candidate gene for the basal cell nevus syndrome

31 March 2020

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Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

31 March 2020

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Activating Smoothened mutations in sporadic basal-cell carcinoma

31 March 2020

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Mutations in SUFU predispose to medulloblastoma

31 March 2020

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Basal cell carcinomas in mice overexpressing sonic hedgehog

31 March 2020

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Basal cell carcinomas in mice overexpressing Gli2 in skin

31 March 2020

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Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice

31 March 2020

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Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

31 March 2020

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The hedgehog pathway and neurological disorders

31 March 2020

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Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

31 March 2020

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Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

31 March 2020

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Small molecule modulation of Smoothened activity

31 March 2020

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Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis

31 March 2020

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Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

31 March 2020

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Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog

31 March 2020

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Medulloblastoma growth inhibition by hedgehog pathway blockade

31 March 2020

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Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

31 March 2020

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In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice.

31 March 2020

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Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies

31 March 2020

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Sonic hedgehog regulates branching morphogenesis in the mammalian lung

31 March 2020

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Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development

31 March 2020

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Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

31 March 2020

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Developmental pathways in musculoskeletal neoplasia: involvement of the Indian Hedgehog-parathyroid hormone-related protein pathway

31 March 2020

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Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation

31 March 2020

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Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

31 March 2020

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Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

31 March 2020

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Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

31 March 2020

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Hedgehog signalling in prostate regeneration, neoplasia and metastasis

31 March 2020

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Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

31 March 2020

1 reference

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CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer

31 March 2020

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Hedgehog signaling promotes prostate xenograft tumor growth

31 March 2020

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Self-renewal and solid tumor stem cells

31 March 2020

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The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells

31 March 2020

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Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells

31 March 2020

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Mammary stem cells, self-renewal pathways, and carcinogenesis

31 March 2020

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Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells

31 March 2020

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Tissue repair and stem cell renewal in carcinogenesis

31 March 2020

1 reference

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The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice

31 March 2020

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The ihog cell-surface proteins bind Hedgehog and mediate pathway activation

31 March 2020

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Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly

31 March 2020

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Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates

31 March 2020

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Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development

31 March 2020

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Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer

31 March 2020

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Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment

31 March 2020

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Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia

31 March 2020

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Sonic hedgehog mRNA expression by real-time quantitative PCR in normal and tumor tissues from colorectal cancer patients

31 March 2020

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Activation of the hedgehog pathway in human hepatocellular carcinomas.

31 March 2020

1 reference

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

31 March 2020

1 reference

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The Hedgehog signaling pathway as a target for anticancer drug discovery

31 March 2020

1 reference

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31 March 2020

Identifiers

DOI

10.1038/NRD2086

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17139287%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

1 reference