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The INK4a/ARF tumor suppressor: one gene--two products--two pathways
scientific article published on 01 August 1998
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scholarly article
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Europe PubMed Central
PubMed publication ID
9757829
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9757829%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
review article
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Europe PubMed Central
title
The INK4a/ARF tumor suppressor: one gene--two products--two pathways
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9757829
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9757829%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
author name string
L Chin
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9757829
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9757829%20AND%20SRC:MED&resulttype=core&format=json
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5 December 2019
J Pomerantz
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9757829
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9757829%20AND%20SRC:MED&resulttype=core&format=json
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5 December 2019
R A DePinho
series ordinal
3
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Europe PubMed Central
PubMed publication ID
9757829
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9757829%20AND%20SRC:MED&resulttype=core&format=json
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5 December 2019
publication date
1 August 1998
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9757829
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9757829%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
number of pages
6
1 reference
based on heuristic
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published in
Trends in Biochemical Sciences
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9757829
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9757829%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
volume
23
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9757829
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9757829%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
issue
8
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9757829
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9757829%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
page(s)
291-296
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9757829
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9757829%20AND%20SRC:MED&resulttype=core&format=json
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5 December 2019
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p53: puzzle and paradigm
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p53-dependent apoptosis suppresses tumor growth and progression in vivo
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p53, the cellular gatekeeper for growth and division
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Lack of p53 mutations and loss of heterozygosity in non-cultured human melanocytic lesions
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A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation
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MDM2--arbiter of p53's destruction
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Mdm2 promotes the rapid degradation of p53
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Regulation of p53 stability by Mdm2
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Amplification of a gene encoding a p53-associated protein in human sarcomas
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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
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Interaction between the retinoblastoma protein and the oncoprotein MDM2
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Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22
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A cell cycle regulator potentially involved in genesis of many tumor types
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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
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Cell-cycle regulators and cancer
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Cdk inhibitors in development and cancer
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Germline p16 mutations in familial melanoma
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Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus
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7 January 2021
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Role of the INK4a locus in tumor suppression and cell mortality.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2898%2901236-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2898%2901236-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2898%2901236-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2898%2901236-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.
1 reference
stated in
Crossref
reference URL
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7 January 2021
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Cooperative effects of INK4a and ras in melanoma susceptibility in vivo
1 reference
stated in
Crossref
reference URL
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7 January 2021
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Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.
1 reference
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7 January 2021
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Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
1 reference
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7 January 2021
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Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2898%2901236-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2898%2901236-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2898%2901236-5
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7 January 2021
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Intragenic mutations of the p16(INK4), p15(INK4B) and p18 genes in primary non-small-cell lung cancers
1 reference
stated in
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https://api.crossref.org/works/10.1016%2FS0968-0004%2898%2901236-5
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7 January 2021
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Identifiers
DOI
10.1016/S0968-0004(98)01236-5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9757829
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9757829%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
PubMed publication ID
9757829
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9757829
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9757829%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
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