(Q7434196)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9BQB4

Sclerostin

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9BQB4

Cystine knot, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

transcription factor binding

1 reference

8 April 2019

Control of the SOST bone enhancer by PTH using MEF2 transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

protein binding

5 references

8 April 2019

Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

8 April 2019

Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

8 April 2019

Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

8 April 2019

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

8 April 2019

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

heparin binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

1 reference

8 April 2019

cell component

extracellular matrix

1 reference

27 February 2018

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BQB4&geneProductId=UniProtKB:Q9BQB4

Golgi apparatus

Ensembl genome database project

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

protein-containing complex

Ensembl genome database project

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

collagen-containing extracellular matrix

HDA

1 reference

8 April 2019

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

HDA

biological process

Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

1 reference

8 April 2019

negative regulation of BMP signaling pathway

1 reference

8 April 2019

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

positive regulation of transcription, DNA-templated

IMP

1 reference

8 April 2019

Control of the SOST bone enhancer by PTH using MEF2 transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

response to mechanical stimulus

IMP

IEP

1 reference

8 April 2019

Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

negative regulation of protein-containing complex assembly

IEP

1 reference

8 April 2019

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification

1 reference

27 February 2018

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BQB4&geneProductId=UniProtKB:Q9BQB4

cellular response to parathyroid hormone stimulus

1 reference

8 April 2019

Control of the SOST bone enhancer by PTH using MEF2 transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

ossification

Ensembl genome database project

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

negative regulation of ossification

Control of the SOST bone enhancer by PTH using MEF2 transcription factors

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

NAS

8 April 2019

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB4

8 April 2019

http://purl.uniprot.org/uniprot/Q9BQB4

exact match

1 reference

Identifiers.org

has part(s)

Cystine knot, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9BQB4

Identifiers

MeSH descriptor ID

C480733

subject named as

SOSTDC1 protein, human

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

5 August 2016

language of work or name

1 reference

5 August 2016

language of work or name

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023