(Q60912966)

2

0 references

Md Shahedur Rahman

3

0 references

Mohammad Abu Hena Mostofa Jamal

4

0 references

S M Khaledur Rahman

5

0 references

S M Riazul Islam

6

0 references

Ki-Hyun Kim

Molecular Therapy. Nucleic acids

7

0 references

language of work or name

English

0 references

publication date

6 December 2018

0 references

published in

0 references

volume

14

0 references

page(s)

212-238

0 references

cites work

Strand-specificity in the transformation of yeast with synthetic oligonucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Redesigning the DNA-binding specificity of a zinc finger protein: a data base-guided approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Homologous recombination involving small single-stranded oligonucleotides in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Altering the genome by homologous recombination

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Zinc finger phage: affinity selection of fingers with new DNA-binding specificities

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

A common mutation in the FACC gene causes Fanconi anaemia in Ashkenazi Jews

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA.DNA oligonucleotide

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

HIV-1 infection in an individual homozygous for the CCR5 deletion allele

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Global distribution of the CCR5 gene 32-basepair deletion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Structure of the multimodular endonuclease FokI bound to DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Structure of FokI has implications for DNA cleavage

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Stable and inheritable changes in genotype and phenotype of albino melanocytes induced by an RNA-DNA oligonucleotide

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Chromosome abnormalities in human embryos

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Development of the human dispermic embryo

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Expressing the human genome

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Homozygous and heterozygous CCR5-Delta32 genotypes are associated with resistance to HIV infection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Rearrangement of side-chains in a Zif268 mutant highlights the complexities of zinc finger-DNA recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Gene silencing in mammals by small interfering RNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Human T-Cell Lymphotropic Virus Type I and Neurological Diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Chimeric nucleases stimulate gene targeting in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Haemophilias A and B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

The structure of human hemoglobin. I. The separation of the alpha and beta chains and their amino acid composition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Mechanism and regulation of human non-homologous DNA end-joining

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Unmodified oligodeoxynucleotides require single-strandedness to induce targeted repair of a chromosomal EGFP gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Camptothecin enhances the frequency of oligonucleotide-directed gene repair in mammalian cells by inducing DNA damage and activating homologous recombination

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Mechanism of DNA double-strand break repair by non-homologous end joining

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Gene targeting using zinc finger nucleases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Targeted gene repair activates Chk1 and Chk2 and stalls replication in corrected cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

DNA double-strand break repair: all's well that ends well

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Targeted chromosomal gene modification in human cells by single-stranded oligodeoxynucleotides in the presence of a DNA double-strand break

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Insights into effective RNAi gained from large-scale siRNA validation screening

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Progress and prospects: targeted gene alteration (TGA).

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Non-homologous end-joining, a sticky affair

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

DNA replication, cell cycle progression and the targeted gene repair reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Unexpected failure rates for modular assembly of engineered zinc fingers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Ooplasmic and nuclear transfer to prevent mitochondrial DNA disorders: conceptual and normative issues

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Progress and prospects: zinc-finger nucleases as gene therapy agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Hemoglobin research and the origins of molecular medicine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Short motif sequences determine the targets of the prokaryotic CRISPR defence system

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Xanthomonas AvrBs3 family-type III effectors: discovery and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Precise genome modification in the crop species Zea mays using zinc-finger nucleases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Knockout rats via embryo microinjection of zinc-finger nucleases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Advances in antisense oligonucleotide development for target identification, validation, and as novel therapeutics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Heritable targeted mutagenesis in maize using a designed endonuclease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

A simple cipher governs DNA recognition by TAL effectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Breaking the code of DNA binding specificity of TAL-type III effectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Adeno-associated virus gene repair corrects a mouse model of hereditary tyrosinemia in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Transient cold shock enhances zinc-finger nuclease-mediated gene disruption.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

The immense potential of xenotransplantation in surgery

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Progress and prospects: oligonucleotide-directed gene modification in mouse embryonic stem cells: a route to therapeutic application.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Disease correction the iPSC way: advances in iPSC-based therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease-mediated safe harbor targeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Species-specific variation in RELA underlies differences in NF-κB activity: a potential role in African swine fever pathogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Targeted mutagenesis of duplicated genes in soybean with zinc-finger nucleases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Generation of PPARγ mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

CRISPR-based adaptive immune systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

In vivo genome editing restores haemostasis in a mouse model of haemophilia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Long-term persistence of a polyclonal T cell repertoire after gene therapy for X-linked severe combined immunodeficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Highly efficient modification of beta-lactoglobulin (BLG) gene via zinc-finger nucleases in cattle

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

TAL effectors: customizable proteins for DNA targeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Pig gene knockout by rAAV-mediated homologous recombination: comparison of BRCA1 gene knockout efficiency in Yucatan and Göttingen fibroblasts with slightly different target sequences.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

CRISPR-Cas systems in bacteria and archaea: versatile small RNAs for adaptive defense and regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Safe harbours for the integration of new DNA in the human genome

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Structural Basis for Sequence-Specific Recognition of DNA by TAL Effectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

https://pubmed.ncbi.nlm.nih.gov/30641475

1 reference

12 December 2020

Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

RNA-guided genetic silencing systems in bacteria and archaea

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Human induced pluripotent stem cells and neurodegenerative disease: prospects for novel therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Tiptoeing around transgenics

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Deployment of new biotechnologies in plant breeding

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

FLASH assembly of TALENs for high-throughput genome editing

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Transcriptional activation ofBrassica napusβ-ketoacyl-ACP synthase II with an engineered zinc finger protein transcription factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

High-efficiency TALEN-based gene editing produces disease-resistant rice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

TAL Effector-Nucleotide Targeter (TALE-NT) 2.0: tools for TAL effector design and target prediction

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

The requirement for recombination factors differs considerably between different pathways of homologous double-strand break repair in somatic plant cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

A porcine model of familial adenomatous polyposis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

In vivo genome editing using a high-efficiency TALEN system

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Efficient TALEN-mediated gene knockout in livestock

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Precision editing of large animal genomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Transcription activator-like effector nucleases enable efficient plant genome engineering.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Gene knockout and knockin by zinc-finger nucleases: current status and perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

A ligation-independent cloning technique for high-throughput assembly of transcription activator–like effector genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

A TALEN genome-editing system for generating human stem cell-based disease models

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Multiplex genome engineering using CRISPR/Cas systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

RNA-guided human genome engineering via Cas9

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Rapid and efficient gene modification in rice and Brachypodium using TALENs

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Human pluripotent stem cells: an emerging model in developmental biology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Cellular and molecular mechanisms involved in the establishment of HIV-1 latency

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

RNA-programmed genome editing in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

A novel therapeutic molecule against HTLV-1 infection targeting provirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

A library of TAL effector nucleases spanning the human genome

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

A CRISPR way to engineer the human genome

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Plant genome engineering with sequence-specific nucleases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

The basic principles of chimeric antigen receptor design

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Site-directed nucleases: a paradigm shift in predictable, knowledge-based plant breeding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

TAL effector nucleases induce mutations at a pre-selected location in the genome of primary barley transformants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Targeted molecular trait stacking in cotton through targeted double-strand break induction

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

DNA targeting specificity of RNA-guided Cas9 nucleases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Targeted Myostatin Gene Editing in Multiple Mammalian Species Directed by a Single Pair of TALE Nucleases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Seamless correction of the sickle cell disease mutation of the HBB gene in human induced pluripotent stem cells using TALENs

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Heritable gene targeting in the mouse and rat using a CRISPR-Cas system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Targeted genome modification of crop plants using a CRISPR-Cas system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Small-interfering RNAs (siRNAs) as a promising tool for ocular therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Trait stacking via targeted genome editing.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Efficient genome editing in plants using a CRISPR/Cas system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

https://pubmed.ncbi.nlm.nih.gov/30641475

1 reference

12 December 2020

Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Heritable custom genomic modifications in Caenorhabditis elegans via a CRISPR-Cas9 system

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Directed evolution of the TALE N-terminal domain for recognition of all 5' bases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

E-TALEN: a web tool to design TALENs for genome engineering.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Efficient nonmeiotic allele introgression in livestock using custom endonucleases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Live pigs produced from genome edited zygotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

RNA-guided genome editing for target gene mutations in wheat

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Generation of interleukin-2 receptor gamma gene knockout pigs from somatic cells genetically modified by zinc finger nuclease-encoding mRNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Transcription activator-like effector nuclease (TALEN)-mediated gene correction in integration-free β-thalassemia induced pluripotent stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

From Agrobacterium to viral vectors: genome modification of plant cells by rare cutting restriction enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Repurposing CRISPR/Cas9 for in situ functional assays.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

TAL effector specificity for base 0 of the DNA target is altered in a complex, effector- and assay-dependent manner by substitutions for the tryptophan in cryptic repeat -1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Correction of a genetic disease in mouse via use of CRISPR-Cas9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Precise plant breeding using new genome editing techniques: opportunities, safety and regulation in the EU.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Genetic screens in human cells using the CRISPR-Cas9 system

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Genome-scale CRISPR-Cas9 knockout screening in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Breakthrough of the year 2013. Cancer immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

A cut above the rest: targeted genome editing technologies in human pluripotent stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Effective gene targeting in rabbits using RNA-guided Cas9 nucleases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

DNA replicons for plant genome engineering.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Combinatorial gene editing in mammalian cells using ssODNs and TALENs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

One-step generation of knockout pigs by zygote injection of CRISPR/Cas system

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Targeted mutagenesis in Zea mays using TALENs and the CRISPR/Cas system

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

True-breeding targeted gene knock-out in barley using designer TALE-nuclease in haploid cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

A guide to genome engineering with programmable nucleases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Cancer mouse models: past, present and future

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Polyglutamine Disease Modeling: Epitope Based Screen for Homologous Recombination using CRISPR/Cas9 System

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

CRISPR-Cas systems: Prokaryotes upgrade to adaptive immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

The position of DNA cleavage by TALENs and cell synchronization influences the frequency of gene editing directed by single-stranded oligonucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Human-induced pluripotent stem cells: potential for neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Improved soybean oil quality by targeted mutagenesis of the fatty acid desaturase 2 gene family

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Targeted genome editing in human repopulating haematopoietic stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Gene targeting using the Agrobacterium tumefaciens-mediated CRISPR-Cas system in rice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by CRISPR/Cas9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Using RNA-seq and targeted nucleases to identify mechanisms of drug resistance in acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

CRISPR-mediated direct mutation of cancer genes in the mouse liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Large chromosomal deletions and heritable small genetic changes induced by CRISPR/Cas9 in rice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Genome edited sheep and cattle.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Evolution of the CRISPR-Cas adaptive immunity systems in prokaryotes: models and observations on virus-host coevolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

CRISPR-Cas9 knockin mice for genome editing and cancer modeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

An AAVS1-targeted minigene platform for correction of iPSCs from all five types of chronic granulomatous disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Synthesizing AND gate genetic circuits based on CRISPR-Cas9 for identification of bladder cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Patient-derived models of acquired resistance can identify effective drug combinations for cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Genome editing in human stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

RNA interference and its role in cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Simple and rapid in vivo generation of chromosomal rearrangements using CRISPR/Cas9 technology

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Targeting Hepatitis B Virus With CRISPR/Cas9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Improved hematopoietic differentiation efficiency of gene-corrected beta-thalassemia induced pluripotent stem cells by CRISPR/Cas9 system

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

The CRISPR/Cas9 system for plant genome editing and beyond

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Fanconi anemia gene editing by the CRISPR/Cas9 system

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Molecular scissors and their application in genetically modified farm animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Therapeutic genome editing: prospects and challenges

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Production of Gene-Corrected Adult Beta Globin Protein in Human Erythrocytes Differentiated from Patient iPSCs After Genome Editing of the Sickle Point Mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

CRISPR-Cas9: a new and promising player in gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

In vivo genome editing using Staphylococcus aureus Cas9

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

The therapeutic application of CRISPR/Cas9 technologies for HIV.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Targeted genome modifications in soybean with CRISPR/Cas9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Applications of the CRISPR-Cas9 system in cancer biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Novel Genome-Editing Tools to Model and Correct Primary Immunodeficiencies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Fanconi Anemia: Overview of the Disease and the Role of Hematopoietic Transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Functional Correction of Large Factor VIII Gene Chromosomal Inversions in Hemophilia A Patient-Derived iPSCs Using CRISPR-Cas9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Induced Pluripotent Stem Cells Derived from Alzheimer's Disease Patients: The Promise, the Hope and the Path Ahead.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Targeted mutations in myostatin by zinc-finger nucleases result in double-muscled phenotype in Meishan pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Application of genome editing technologies to the study and treatment of hematological disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Minimizing off-Target Mutagenesis Risks Caused by Programmable Nucleases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Origins of Programmable Nucleases for Genome Engineering

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Off-target Effects in CRISPR/Cas9-mediated Genome Engineering

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Phylogenetic Distribution of CRISPR-Cas Systems in Antibiotic-Resistant Pseudomonas aeruginosa

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

In vivo gene editing in dystrophic mouse muscle and muscle stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome Editing

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Corrigendum: Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

On the Origin of CRISPR-Cas Technology: From Prokaryotes to Mammals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Type I CRISPR-Cas targets endogenous genes and regulates virulence to evade mammalian host immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Insertional Mutagenesis by CRISPR/Cas9 Ribonucleoprotein Gene Editing in Cells Targeted for Point Mutation Repair Directed by Short Single-Stranded DNA Oligonucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Modern Genome Editing Technologies in Huntington's Disease Research

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Programmable Genome Editing Tools and their Regulation for Efficient Genome Engineering

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Regulation of CRISPR-Cas adaptive immune systems.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Genome editing and genetic engineering in livestock for advancing agricultural and biomedical applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Gene therapy for Wiskott-Aldrich syndrome in a severely affected adult

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Generation of a gene-corrected isogenic control iPSC line from cystic fibrosis patient-specific iPSCs homozygous for p.Phe508del mutation mediated by TALENs and ssODN.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Molecular genetics and emerging therapies for retinitis pigmentosa: Basic research and clinical perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Update on the clinical utility of an RNA interference-based treatment: focus on Patisiran.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

In vivo genome editing via the HITI method as a tool for gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Molecular biology at the cutting edge: A review on CRISPR/CAS9 gene editing for undergraduates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

High Efficiency Gene Correction in Hematopoietic Cells by Donor-Template-Free CRISPR/Cas9 Genome Editing.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Cas9-nickase-mediated genome editing corrects hereditary tyrosinemia in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Zinc Fingers, TALEs, and CRISPR Systems: A Comparison of Tools for Epigenome Editing.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Emerging applications of genome-editing technology to examine functionality of GWAS-associated variants for complex traits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell Type Specific Gene Editing.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Strategies for In Vivo Genome Editing in Nondividing Cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Detection and Quantification of HDR and NHEJ Induced by Genome Editing at Endogenous Gene Loci Using Droplet Digital PCR

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Innovative Therapeutic Strategies for Cystic Fibrosis: Moving Forward to CRISPR Technique.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

The CRISPR tool kit for genome editing and beyond.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Cattle with a precise, zygote-mediated deletion safely eliminate the major milk allergen beta-lactoglobulin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Chimeric Antigen Receptor T-Cells (CAR T-Cells) for Cancer Immunotherapy - Moving Target for Industry?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020

Detection of myostatin gene MSTN in some goat breeds (Capra hircus)

1 reference

https://pubmed.ncbi.nlm.nih.gov/30641475

12 December 2020