(Q60651239)

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The protein tyrosine phosphatase PTPN22 controls forkhead box protein 3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization

scientific article published on 01 October 2014

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Europe PubMed Central

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20 March 2020

The protein tyrosine phosphatase PTPN22 controls forkhead box protein 3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization (English)

1 reference

Europe PubMed Central

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20 March 2020

Georgia Fousteri

1

1 reference

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20 March 2020

Manuela Battaglia

7

1 reference

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20 March 2020

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T Jofra

2

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20 March 2020

I Debernardis

3

1 reference

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20 March 2020

S M Stanford

4

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20 March 2020

A Laurenzi

5

1 reference

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20 March 2020

N Bottini

6

1 reference

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20 March 2020

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1 October 2014

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20 March 2020

Clinical and Experimental Immunology

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20 March 2020

178

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20 March 2020

1

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20 March 2020

178-189

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20 March 2020

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low-dose antigen promotes induction of FOXP3 in human CD4+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type-I IFN drives the differentiation of short-lived effector CD8+ T cells in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induced CD4+Foxp3+ regulatory T cells in immune tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCR affinity and specificity requirements for human regulatory T-cell function

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LYP inhibits T-cell activation when dissociated from CSK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein tyrosine phosphatases in lymphocyte activation and autoimmunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTPN22 alters the development of regulatory T cells in the thymus

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biology and pathogenesis of lymphocytic choriomeningitis virus infection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo instruction of suppressor commitment in naive T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of IL-4-producing CD4+ T cells by antigenic peptides altered for TCR binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms underlying FOXP3 induction in human T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of intestinal inflammation by regulatory T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping and restriction of a dominant viral CD4+ T cell core epitope by both MHC class I and MHC class II.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: OX40 inhibits TGF-beta- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type I interferon during viral infections: multiple triggers for a multifunctional mediator.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD103 is dispensable for anti-viral immunity and autoimmunity in a mouse model of virally-induced autoimmune diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A central role for induced regulatory T cells in tolerance induction in experimental colitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PEST family phosphatases in immunity, autoimmunity, and autoinflammatory disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of regulatory T cell lineage commitment and maintenance

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of foxp3+ T regulatory cell-mediated suppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant role of antigen dose in CD4+Foxp3+ regulatory T cell induction and expansion

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiation of effector CD4 T cell populations (*)

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased memory conversion of naïve CD8 T cells activated during late phases of acute virus infection due to decreased cumulative antigen exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD28 costimulation regulates FOXP3 in a RelA/NF-κB-dependent mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24905474

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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