(Q55080794)

http://europepmc.org/abstract/PMC/5928049

18 June 2018

title

Pathway-based dissection of the genomic heterogeneity of cancer hallmarks' acquisition with SLAPenrich. (English)

1 reference

http://europepmc.org/abstract/PMC/5928049

18 June 2018

author

Francesco Iorio

1

1 reference

http://europepmc.org/abstract/PMC/5928049

18 June 2018

Ultan McDermott

6

1 reference

http://europepmc.org/abstract/PMC/5928049

18 June 2018

Julio Saez-Rodriguez

7

1 reference

http://europepmc.org/abstract/PMC/5928049

18 June 2018

author name string

Luz Garcia-Alonso

2

1 reference

http://europepmc.org/abstract/PMC/5928049

18 June 2018

Jonathan S Brammeld

3

1 reference

http://europepmc.org/abstract/PMC/5928049

18 June 2018

Iňigo Martincorena

4

1 reference

http://europepmc.org/abstract/PMC/5928049

18 June 2018

David R Wille

5

1 reference

http://europepmc.org/abstract/PMC/5928049

18 June 2018

language of work or name

English

0 references

publication date

30 April 2018

1 reference

http://europepmc.org/abstract/PMC/5928049

18 June 2018

published in

Scientific Reports

1 reference

http://europepmc.org/abstract/PMC/5928049

18 June 2018

volume

8

1 reference

http://europepmc.org/abstract/PMC/5928049

18 June 2018

issue

1

1 reference

http://europepmc.org/abstract/PMC/5928049

18 June 2018

page(s)

6713

1 reference

http://europepmc.org/abstract/PMC/5928049

18 June 2018

copyright license

Creative Commons Attribution 4.0 International

start time

30 April 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

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18 June 2018

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18 June 2018

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18 June 2018

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18 June 2018

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18 June 2018

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Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

18 June 2018

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A multilevel pan-cancer map links gene mutations to cancer hallmarks

18 June 2018

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Emerging cytokine networks in colorectal cancer.

18 June 2018

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Identifying Driver Genomic Alterations in Cancers by Searching Minimum-Weight, Mutually Exclusive Sets

18 June 2018

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New Insight on the Role of Plasminogen Receptor in Cancer Progression

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

TiMEx: a waiting time model for mutually exclusive cancer alterations

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Pathway and network analysis of cancer genomes

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

18 June 2018

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Pembrolizumab for the treatment of non-small-cell lung cancer

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Pembrolizumab versus Ipilimumab in Advanced Melanoma

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Hypoxia/reoxygenation-experienced cancer cell migration and metastasis are regulated by Rap1- and Rac1-GTPase activation via the expression of thymosin beta-4.

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

In silico prescription of anticancer drugs to cohorts of 28 tumor types reveals targeting opportunities

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Two decades beyond BRCA1/2: Homologous recombination, hereditary cancer risk and a target for ovarian cancer therapy

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Androgen receptor signaling regulates growth of glioblastoma multiforme in men.

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Oncostatin M receptor is a novel therapeutic target in cervical squamous cell carcinoma.

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Discovery and saturation analysis of cancer genes across 21 tumour types

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

The Cancer Genome Atlas Pan-Cancer analysis project

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Network-based stratification of tumor mutations

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Signatures of mutational processes in human cancer

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

OncodriveCLUST: exploiting the positional clustering of somatic mutations to identify cancer genes

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

MicroRNAs in skin response to UV radiation

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

The detection and implication of genome instability in cancer

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Pathway-based personalized analysis of cancer

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Lessons from the cancer genome

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

18 June 2018

Cancer genome landscapes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis.

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Reversing the Warburg effect as a treatment for glioblastoma

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Functional impact bias reveals cancer drivers

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Camera: a competitive gene set test accounting for inter-gene correlation

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Systematic identification of genomic markers of drug sensitivity in cancer cells

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Mutual exclusivity analysis identifies oncogenic network modules

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

De novo discovery of mutated driver pathways in cancer

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

g:Profiler--a web server for functional interpretation of gene lists (2011 update).

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

PathScan: a tool for discerning mutational significance in groups of putative cancer genes

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Principles and strategies for developing network models in cancer

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Hallmarks of Cancer: The Next Generation

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

The ATM kinase induces microRNA biogenesis in the DNA damage response.

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Identifying cancer driver genes in tumor genome sequencing studies

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Pathway Commons, a web resource for biological pathway data

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Microsatellite instability in colorectal cancer

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

International network of cancer genome projects

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Immunity, Inflammation, and Cancer

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Platelet-derived growth factor-receptor alpha strongly inhibits melanoma growth in vitro and in vivo

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Activation of Rap1 promotes prostate cancer metastasis

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Combinatorial patterns of somatic gene mutations in cancer

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Loss of oncostatin M receptor beta in metastatic melanoma cells

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Matrix metalloproteinases and tumor metastasis

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Regulation of cancer cell motility through actin reorganization

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Statistical significance for genomewide studies

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Guidelines for human gene nomenclature

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

The role of the plasminogen activation system in angiogenesis and metastasis

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Serum interleukin 6 and C-reactive protein levels correlate with resistance to IL-2 therapy and poor survival in melanoma patients

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Pathway level alterations rather than mutations in single genes predict response to HER2-targeted therapies in the neo-ALTTO trial.

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Genomic hallmarks of homologous recombination deficiency in invasive breast carcinomas.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

Exploiting combinatorial patterns in cancer genomic data for personalized therapy and new target discovery

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

High-throughput oncogene mutation profiling in human cancer

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928049

PathScore: a web tool for identifying altered pathways in cancer data

30 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41598-018-25076-6

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/S41598-018-25076-6

1 reference

http://europepmc.org/abstract/PMC/5928049

18 June 2018

PMC publication ID

5928049

1 reference

http://europepmc.org/abstract/PMC/5928049

18 June 2018

PubMed publication ID

29713020

1 reference