(Q53338153)

13 May 2018

http://europepmc.org/abstract/MED/10575009

title

The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation. (English)

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10575009

1 reference

Jacobsen H

1

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10575009

Reinhardt D

2

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10575009

Brockhaus M

3

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10575009

Bur D

4

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10575009

Kocyba C

5

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10575009

Kurt H

6

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10575009

Grim MG

7

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10575009

Baumeister R

8

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10575009

Loetscher H

9

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10575009

language of work or name

English

0 references

publication date

1 December 1999

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10575009

published in

Journal of Biological Chemistry

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10575009

volume

274

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10575009

issue

49

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10575009

page(s)

35233-35239

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10575009

cites work

A familial Alzheimer's disease locus on chromosome 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Presenilins: genes for life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Alternative Cleavage of Alzheimer-Associated Presenilins During Apoptosis by a Caspase-3 Family Protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Presenilins Are Processed by Caspase-type Proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Proteolysis by presenilins and the renaissance of tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Endoproteolytic Processing and Stabilization of Wild-type and Mutant Presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Protein topology of presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Subcellular distribution and turnover of presenilins in transfected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

Determination of a cleavage site of presenilin 2 protein in stably transfected SH-SY5Y human neuroblastoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.49.35233

21 January 2018

Identifiers

DOI

10.1074/JBC.274.49.35233

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10575009

1 reference

13 May 2018