(Q52575042)

3 May 2018

http://europepmc.org/abstract/MED/17110406

title

Chloride and the endosomal-lysosomal pathway: emerging roles of CLC chloride transporters. (English)

1 reference

3 May 2018

http://europepmc.org/abstract/MED/17110406

author

Thomas Jentsch

series ordinal

1

1 reference

3 May 2018

http://europepmc.org/abstract/MED/17110406

language of work or name

English

0 references

publication date

16 November 2006

1 reference

3 May 2018

http://europepmc.org/abstract/MED/17110406

published in

Journal of Physiology

1 reference

3 May 2018

http://europepmc.org/abstract/MED/17110406

volume

578

1 reference

3 May 2018

http://europepmc.org/abstract/MED/17110406

issue

Pt 3

1 reference

3 May 2018

http://europepmc.org/abstract/MED/17110406

page(s)

633-640

1 reference

3 May 2018

http://europepmc.org/abstract/MED/17110406

cites work

CLC-3 channels modulate excitatory synaptic transmission in hippocampal neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Lysosomal storage disease upon disruption of the neuronal chloride transport protein ClC-6.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Kidney-specific upregulation of vitamin D3 target genes in ClC-5 KO mice.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Separate ion pathways in a Cl-/H+ exchanger

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Intracellular localization of ClC chloride channels and their ability to form hetero-oligomers

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Impaired acidification in early endosomes of ClC-5 deficient proximal tubule

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Physiological functions of CLC Cl- channels gleaned from human genetic disease and mouse models

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

The ClC-5 chloride channel knock-out mouse - an animal model for Dent's disease.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

The ClC-3 chloride channel promotes acidification of lysosomes in CHO-K1 and Huh-7 cells

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Albers-Schönberg disease (autosomal dominant osteopetrosis, type II) results from mutations in the ClCN7 chloride channel gene

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Mutational analysis demonstrates that ClC-4 and ClC-5 directly mediate plasma membrane currents.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

X-linked hypercalciuric nephrolithiasis: clinical syndromes and chloride channel mutations

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Molecular identification of a volume-regulated chloride channel

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Heteromultimeric CLC chloride channels with novel properties

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Two physically distinct pores in the dimeric ClC-0 chloride channel.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Homodimeric architecture of a ClC-type chloride ion channel

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

A common molecular basis for three inherited kidney stone diseases

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Pores Formed by Single Subunits in Mixed Dimers of Different CLC Chloride Channels

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151350

Biophysical properties of ClC-3 differentiate it from swelling-activated chloride channels in Chinese hamster ovary-K1 cells

30 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17110406

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The nitrate/proton antiporter AtCLCa mediates nitrate accumulation in plant vacuoles

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17110406

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1113/JPHYSIOL.2006.124719

1 reference

3 May 2018

http://europepmc.org/abstract/MED/17110406

PMC publication ID

2151350

0 references

1 reference

3 May 2018