(Q51236137)

http://www.ebi.ac.uk/interpro/protein/Q24592

Protein kinase-like domain superfamily

1 reference

http://www.ebi.ac.uk/interpro/protein/Q24592

membrane protein

1 reference

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Band 4.1 domain, protein family

1 reference

FERM domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

1 reference

8 April 2019

protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

6 references

8 April 2019

8 April 2019

The roles of JAK/STAT signaling in Drosophila immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

8 April 2019

Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

8 April 2019

8 April 2019

Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

non-membrane spanning protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

1 reference

8 April 2019

signaling receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

1 reference

16 July 2018

cytokine receptor binding

IPI

1 reference

8 April 2019

Mechanisms of JAK/STAT pathway negative regulation by the short coreceptor Eye Transformer/Latran.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

IPI

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

1 reference

8 April 2019

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

1 reference

8 April 2019

cell component

cytoplasm

1 reference

8 April 2019

The JAK-STAT pathway in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

1 reference

8 April 2019

cytoplasmic side of plasma membrane

1 reference

8 April 2019

Polarized subcellular localization of Jak/STAT components is required for efficient signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

endomembrane system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

1 reference

8 April 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

1 reference

8 April 2019

extrinsic component of cytoplasmic side of plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

1 reference

16 July 2018

compound eye morphogenesis

biological process

1 reference

8 April 2019

Long-range effect of upd, a ligand for Jak/STAT pathway, on cell cycle in Drosophila eye development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

compound eye photoreceptor cell differentiation

1 reference

8 April 2019

The Drosophila Jak kinase hopscotch is required for multiple developmental processes in the eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

apical constriction

1 reference

8 April 2019

Repression of Wasp by JAK/STAT signalling inhibits medial actomyosin network assembly and apical cell constriction in intercalating epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

1 reference

16 July 2018

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

1 reference

16 July 2018

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

1 reference

8 April 2019

immune response

1 reference

8 April 2019

The evolution and genetics of innate immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

humoral immune response

1 reference

8 April 2019

The roles of JAK/STAT signaling in Drosophila immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

transmembrane receptor protein tyrosine kinase signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

1 reference

16 July 2018

receptor signaling pathway via JAK-STAT

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

6 references

24 April 2018

24 April 2018

The roles of JAK/STAT signaling in Drosophila immune responses

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

24 April 2018

The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

24 April 2018

The fertile field of Drosophila Jak/STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

24 April 2018

Eye transformer is a negative regulator of Drosophila JAK/STAT signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

24 April 2018

Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

multicellular organism development

IGI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

1 reference

8 April 2019

border follicle cell migration

periodic partitioning

1 reference

8 April 2019

Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

nervous system development

1 reference

8 April 2019

Patterns and functions of STAT activation during Drosophila embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

eye-antennal disc morphogenesis

1 reference

8 April 2019

JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

primary sex determination

1 reference

8 April 2019

The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

long-term memory

1 reference

8 April 2019

Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

cell population proliferation

1 reference

8 April 2019

Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

1 reference

8 April 2019

ommatidial rotation

1 reference

8 April 2019

The JAK/STAT pathway and Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

regulation of embryonic cell shape

1 reference

8 April 2019

Repression of Wasp by JAK/STAT signalling inhibits medial actomyosin network assembly and apical cell constriction in intercalating epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

stem cell population maintenance

1 reference

8 April 2019

Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

ovarian follicle cell development

1 reference

8 April 2019

A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

ovarian follicle cell stalk formation

1 reference

8 April 2019

Drosophila follicle cells are patterned by multiple levels of Notch signaling and antagonism between the Notch and JAK/STAT pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

positive regulation of heterochromatin assembly

1 reference

8 April 2019

Drosophila linker histone H1 coordinates STAT-dependent organization of heterochromatin and suppresses tumorigenesis caused by hyperactive JAK-STAT signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

larval lymph gland hemopoiesis

1 reference

8 April 2019

The Friend of GATA protein U-shaped functions as a hematopoietic tumor suppressor in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

lamellocyte differentiation

1 reference

8 April 2019

The roles of JAK/STAT signaling in Drosophila immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

hemocyte proliferation

1 reference

8 April 2019

The roles of JAK/STAT signaling in Drosophila immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

regulation of hemocyte proliferation

1 reference

8 April 2019

Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

peptidyl-tyrosine autophosphorylation

1 reference

8 April 2019

Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

establishment of ommatidial planar polarity

1 reference

8 April 2019

The Drosophila Jak kinase hopscotch is required for multiple developmental processes in the eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

germ-line stem cell division

1 reference

8 April 2019

The stem-cell niche theory: lessons from flies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

hemocyte differentiation

1 reference

8 April 2019

The Hopscotch Jak kinase requires the Raf pathway to promote blood cell activation and differentiation in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

1 reference

16 July 2018

locomotor rhythm

1 reference

8 April 2019

Regulation of circadian behavioral output via a MicroRNA-JAK/STAT circuit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

regulation of hemocyte differentiation

1 reference

10 September 2018

A directed screen for genes involved in Drosophila blood cell activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

regulation of receptor signaling pathway via JAK-STAT

1 reference

8 April 2019

The roles of JAK/STAT signaling in Drosophila immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

somatic stem cell division

1 reference

8 April 2019

The stem-cell niche theory: lessons from flies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

oogenesis

1 reference

5 June 2018

The fertile field of Drosophila Jak/STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24592&geneProductId=UniProtKB:Q24592

defense response to virus

mediolateral intercalation

1 reference

8 April 2019

Repression of Wasp by JAK/STAT signalling inhibits medial actomyosin network assembly and apical cell constriction in intercalating epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

receptor signaling pathway via JAK-STAT

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

6 references

8 April 2019

8 April 2019

The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

8 April 2019

The roles of JAK/STAT signaling in Drosophila immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

8 April 2019

Eye transformer is a negative regulator of Drosophila JAK/STAT signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

8 April 2019

Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

IGI

8 April 2019

Identification of JAK/STAT signalling components by genome-wide RNA interference.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

border follicle cell migration

1 reference

8 April 2019

A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

wing disc morphogenesis

1 reference

8 April 2019

JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

leg disc morphogenesis

1 reference

8 April 2019

JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

haltere disc morphogenesis

1 reference

8 April 2019

JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24592

has part(s)

protein kinase domain

1 reference

http://www.ebi.ac.uk/interpro/protein/Q24592

FERM domain

1 reference

http://www.ebi.ac.uk/interpro/protein/Q24592

Band 4.1 domain

1 reference

http://www.ebi.ac.uk/interpro/protein/Q24592

protein kinase, ATP binding site

1 reference

http://www.ebi.ac.uk/interpro/protein/Q24592

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

http://www.ebi.ac.uk/interpro/protein/Q24592

tyrosine-protein kinase, catalytic domain

1 reference

http://www.ebi.ac.uk/interpro/protein/Q24592

tyrosine-protein kinase, active site

1 reference