(Q4734884)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35348

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35348&geneProductId=UniProtKB:P35348

1 reference

27 March 2018

adrenergic receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35348&geneProductId=UniProtKB:P35348

1 reference

16 July 2018

protein heterodimerization activity

IDA

1 reference

8 April 2019

Nuclear localization drives α1-adrenergic receptor oligomerization and signaling in cardiac myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

alpha1-adrenergic receptor activity

IDA

Cloning, functional expression and tissue distribution of human alpha 1c-adrenoceptor splice variants

6 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35348&geneProductId=UniProtKB:P35348

16 July 2018

alpha(1)-adrenoceptor subtypes differentially couple to growth promotion and inhibition in Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35348&geneProductId=UniProtKB:P35348

16 July 2018

Molecular cloning, genomic characterization and expression of novel human alpha1A-adrenoceptor isoforms

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35348&geneProductId=UniProtKB:P35348

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35348&geneProductId=UniProtKB:P35348

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35348&geneProductId=UniProtKB:P35348

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35348&geneProductId=UniProtKB:P35348

protein binding

IPI

1 reference

8 April 2019

MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

alpha1-adrenergic receptor activity

IPI

Cloning, functional expression and tissue distribution of human alpha 1c-adrenoceptor splice variants

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

8 April 2019

alpha(1)-adrenoceptor subtypes differentially couple to growth promotion and inhibition in Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

8 April 2019

Molecular cloning, genomic characterization and expression of novel human alpha1A-adrenoceptor isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

cell component

T-tubule

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

integral component of plasma membrane

1 reference

16 July 2018

Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35348&geneProductId=UniProtKB:P35348

Z discdkac

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

8 April 2019

MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

IDA

caveola

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

1 reference

8 April 2019

dopaminergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

GABA-ergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

integral component of postsynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

integral component of presynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

integral component of plasma membrane

negative regulation of cell population proliferation

biological process

1 reference

8 April 2019

alpha(1)-adrenoceptor subtypes differentially couple to growth promotion and inhibition in Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

intracellular signal transduction

1 reference

8 April 2019

Differential regulation of the phosphatidylinositol 3-kinase/Akt and p70 S6 kinase pathways by the alpha(1A)-adrenergic receptor in rat-1 fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

organ growth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

cell-cell signaling

1 reference

8 April 2019

Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

pilomotor reflex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

regulation of vasoconstriction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

1 reference

8 April 2019

positive regulation of heart rate

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

positive regulation of systemic arterial blood pressure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

4 references

8 April 2019

8 April 2019

alpha(1)-adrenoceptor subtypes differentially couple to growth promotion and inhibition in Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

8 April 2019

urination

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

positive regulation of the force of heart contraction by epinephrine-norepinephrine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

apoptotic process

1 reference

8 April 2019

Differential regulation of the phosphatidylinositol 3-kinase/Akt and p70 S6 kinase pathways by the alpha(1A)-adrenergic receptor in rat-1 fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

smooth muscle contraction

1 reference

8 April 2019

The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

adenylate cyclase-activating adrenergic receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

regulation of cardiac muscle contraction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

1 reference

8 April 2019

positive regulation of heart rate by epinephrine-norepinephrine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

regulation of muscle contraction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

1 reference

8 April 2019

adult heart development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

positive regulation of cytosolic calcium ion concentration

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

positive regulation of vasoconstriction

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

negative regulation of autophagy

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

positive regulation of cardiac muscle hypertrophy

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

positive regulation of non-membrane spanning protein tyrosine kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

cell growth involved in cardiac muscle cell development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

regulation of synaptic vesicle exocytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35348

physically interacts with

1 reference

479

17 August 2016

1 reference

483

17 August 2016

1 reference

505

17 August 2016

1 reference

124

17 August 2016

1 reference

485

17 August 2016

1 reference

3364

17 August 2016

1 reference

7109

17 August 2016

1 reference

9

17 August 2016

1 reference

37

17 August 2016

1 reference

38

17 August 2016

1 reference

277

17 August 2016

1 reference

7170

17 August 2016

1 reference

501

17 August 2016

1 reference

88

17 August 2016

1 reference

43

17 August 2016

1 reference

135

17 August 2016

1 reference

73

17 August 2016

1 reference

502

17 August 2016

1 reference

49

17 August 2016

1 reference

96

17 August 2016

1 reference

97

17 August 2016

1 reference

52

17 August 2016

1 reference

493

17 August 2016

1 reference

99

17 August 2016

1 reference

53

17 August 2016

1 reference

488

17 August 2016

1 reference

7302

17 August 2016

1 reference

56

17 August 2016

1 reference

499

17 August 2016

1 reference

503

English

17 August 2016

isoxsuprine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1197051

epinephrine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL679

norepinephrine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1437

(−)-ephedrine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL211456

methoxamine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201103

dabuzalgron

Partial agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL257978

dipivefrin hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200833

doxazosin mesylate

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200561

oxymetazoline hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200791

phenoxybenzamine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200787

phenylephrine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200339

prazosin hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1558

tamsulosin hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200914

midodrine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200461

alfuzosin hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1723

Gene Atlas image

PBB GE ADRA1A 211492 s at fs.png
732 × 530; 12 KB

0 references

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0