(Q46390923)

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Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15778223

Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15778223

lipopolysaccharide

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phosphorylation

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tumor progression

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based on heuristic

inferred from title

author name string

Jeonghee Cho

1

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15778223

Michael Melnick

2

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15778223

Georgios P Solidakis

3

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15778223

Philip N Tsichlis

4

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15778223

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18 March 2005

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15778223

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15778223

280

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15778223

21

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15778223

20442-20448

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15778223

Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation

1 reference

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21 January 2018

Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation

1 reference

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21 January 2018

Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase

1 reference

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21 January 2018

Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation

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The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cell lines.

1 reference

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21 January 2018

TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105

1 reference

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The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases

1 reference

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21 January 2018

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

1 reference

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Galactosamine-induced sensitization to the lethal effects of endotoxin

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Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

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Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease

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21 January 2018

Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals.

1 reference

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Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40.

1 reference

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21 January 2018

NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase

1 reference

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21 January 2018

Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.

1 reference

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21 January 2018

IkappaB kinase is an essential component of the Tpl2 signaling pathway

1 reference

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21 January 2018

Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site

1 reference

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21 January 2018

Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity

1 reference

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21 January 2018

The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity

1 reference

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21 January 2018

Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide

1 reference

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21 January 2018

Catalysis by a multiprotein IkappaB kinase complex

1 reference

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21 January 2018

NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M413554200

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15778223

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15778223

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