(Q44905183)

7 December 2017

title

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways (English)

1 reference

intraepithelial neoplasia

7 December 2017

0 references

1 reference

11

Massimo Loda

1 reference

7 December 2017

10

Todd R Golub

1 reference

7 December 2017

7

Judith Manola

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7 December 2017

Pradip K Majumder

1

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7 December 2017

Phillip G Febbo

2

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7 December 2017

Rachel Bikoff

3

1 reference

7 December 2017

Raanan Berger

4

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7 December 2017

Qi Xue

5

1 reference

7 December 2017

Louis M McMahon

6

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7 December 2017

James Brugarolas

8

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7 December 2017

Timothy J McDonnell

9

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7 December 2017

Heidi A Lane

12

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7 December 2017

William R Sellers

13

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7 December 2017

language of work or name

English

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publication date

23 May 2004

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7 December 2017

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7 December 2017

volume

10

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7 December 2017

issue

6

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7 December 2017

page(s)

594-601

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

7 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

21 January 2018

1 reference

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Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

1 reference

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Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

21 January 2018

1 reference

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Early clinical experience with a novel rapamycin derivative

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

The impact of bcl-2 expression and bax deficiency on prostate homeostasis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Signal transduction to hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

High frequency of mutations of the PIK3CA gene in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

PIK3CA is implicated as an oncogene in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Bcl-2 proto-oncogene expression in low- and high-grade prostatic intraepithelial neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Mammalian target of rapamycin: a new molecular target for breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Targeting HIF-1 for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

Phase I clinical and pharmacologic study of 13-cis-retinoic acid, interferon alfa, and paclitaxel in patients with prostate cancer and other advanced malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

inferred from DOI database lookup

7 January 2021

based on heuristic

Safety and tolerability of a new oral formulation of cyclosporin A, Sandimmun Neoral, in renal transplant patients

1 reference

https://api.crossref.org/works/10.1038%2FNM1052

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NM1052

1 reference

7 December 2017

1 reference