(Q44885739)

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19 January 2020

title

Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice (English)

1 reference

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19 January 2020

3

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19 January 2020

Gerda Egger

4

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19 January 2020

author name string

Christine B Yoo

1

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19 January 2020

Jody C Chuang

2

1 reference

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19 January 2020

Allen S Yang

5

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19 January 2020

Louis Dubeau

6

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19 January 2020

Tiffany Long

7

1 reference

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19 January 2020

Peter W Laird

8

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19 January 2020

Victor E Marquez

9

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19 January 2020

Peter A Jones

10

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19 January 2020

publication date

19 March 2008

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Cancer Prevention Research

19 January 2020

published in

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19 January 2020

volume

1

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19 January 2020

issue

4

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19 January 2020

page(s)

233-240

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Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer

19 January 2020

cites work

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Potent inhibition of human liver aldehyde oxidase by raloxifene

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

The novel DNA methylation inhibitor zebularine is effective against the development of murine T-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

DNA loss, cell loss and epithelial

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12 December 2020

Inter-strain variability in aldehyde oxidase activity in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Human liver aldehyde oxidase: inhibition by 239 drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Variation of hepatic methotrexate 7-hydroxylase activity in animals and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Involvement of growth hormone as a regulating factor in sex differences of mouse hepatic aldehyde oxidase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Worms gang up on bacteria

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Empirical validation of the S-Score algorithm in the analysis of gene expression data

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

L2L: a simple tool for discovering the hidden significance in microarray expression data

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Simplified mammalian DNA isolation procedure

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Comprehensive analysis of CpG islands in human chromosomes 21 and 22

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Quantitative determination of zebularine (NSC 309132), a DNA methyltransferase inhibitor, and three metabolites in murine plasma by high-performance liquid chromatography coupled with on-line radioactivity detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Global loss of imprinting leads to widespread tumorigenesis in adult mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice: influence of sex and inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

A mass balance and disposition study of the DNA methyltransferase inhibitor zebularine (NSC 309132) and three of its metabolites in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Preferential response of cancer cells to zebularine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Induction of Tumors in Mice by Genomic Hypomethylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Epidermal 'turnover time'--a new examination

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Suppression of intestinal neoplasia by DNA hypomethylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

A genetic model for colorectal tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

The epigenome as a target for cancer chemoprevention

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Purification and characterization of hepatic aldehyde oxidase in male and female mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Inhibition of DNA methylation and reactivation of silenced genes by zebularine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Molecular cloning of the cDNA coding for mouse aldehyde oxidase: tissue distribution and regulation in vivo by testosterone

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

DNA methylation patterns and epigenetic memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

The fundamental role of epigenetic events in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19138966

12 December 2020

10.1158/1940-6207.CAPR-07-0008

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19138966%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

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19 January 2020

PubMed publication ID

19138966

1 reference