(Q44879898)

7 December 2017

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title

The discovery of receptor tyrosine kinases: targets for cancer therapy (English)

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7 December 2017

Andreas Gschwind

1

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7 December 2017

Oliver M Fischer

series ordinal

2

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7 December 2017

Axel Ullrich

series ordinal

3

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7 December 2017

language of work or name

English

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publication date

1 May 2004

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7 December 2017

published in

Nature Reviews Cancer

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7 December 2017

volume

4

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7 December 2017

issue

5

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7 December 2017

page(s)

361-370

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Effects of mouse tumor transplantation on the nervous system

7 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

The stimulation of epidermal proliferation by a specific protein (EGF)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Epidermal growth factor stimulates phosphorylation in membrane preparations in vitro

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Rat Insulin Genes: Construction of Plasmids Containing the Coding Sequences

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Nucleotide sequence of human preproinsulin complementary DNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Insulin-like growth factor II precursor gene organization in relation to insulin gene family

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Human beta-nerve growth factor gene sequence highly homologous to that of mouse

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Human transforming growth factor-alpha: precursor structure and expression in E. coli

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Human Growth Hormone: Complementary DNA Cloning and Expression in Bacteria

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

A new avian erythroblastosis virus, AEV-H, carries erbB gene responsible for the induction of both erythroblastosis and sarcomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Oncogenic kinase signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Signal transduction by allosteric receptor oligomerization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Two EGF molecules contribute additively to stabilization of the EGFR dimer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Epidermal growth factor stimulates guanine nucleotide binding activity and phosphorylation of ras oncogene proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Requirement for c-ras proteins during viral oncogene transformation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Src homology region 2 domains direct protein-protein interactions in signal transduction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

A cytosolic protein catalyzes the release of GDP from p21ras

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Identification of a nucleotide exchange-promoting activity for p21ras

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Signal transduction. How receptors turn Ras on.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Critical role of calcium- dependent epidermal growth factor receptor transactivation in PC12 cell membrane depolarization and bradykinin signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

cag+ Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Strain-dependent epithelial defects in mice lacking the EGF receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Requirement for neuregulin receptor erbB2 in neural and cardiac development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

An essential role for ectodomain shedding in mammalian development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Anti-sense transforming growth factor alpha oligonucleotides inhibit autocrine stimulated proliferation of a colon carcinoma cell line

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Amplification of a novel v-erbB-related gene in a human mammary carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Monoclonal antibodies identify a cell-surface antigen associated with an activated cellular oncogene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

A specific inhibitor of the epidermal growth factor receptor tyrosine kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Epidermal‐Growth‐Factor‐Dependent Activation of the Src‐Family Kinases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Specific inhibition of epidermal growth factor receptor tyrosine kinase by 4-anilinoquinazolines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

VEGF and the quest for tumour angiogenesis factors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Transplacental carcinogenesis by stilbestrol

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Mutational analysis of the tyrosine kinome in colorectal cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC1360

31 March 2020

Identifiers

DOI

10.1038/NRC1360

1 reference

7 December 2017

1 reference