(Q44504054)

English

Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases

scientific article published on 7 July 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

3 December 2017

Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

author name string

David Cortez

1

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

language of work or name

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publication date

7 July 2003

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

3 December 2017

278

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

39

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

37139-37145

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

ATM and ATR: networking cellular responses to DNA damage

1 reference

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Cell cycle checkpoint signaling through the ATM and ATR kinases

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 reference

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ATR and ATRIP: partners in checkpoint signaling

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

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Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast

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ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

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Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

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Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

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A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

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Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

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Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

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SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

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Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

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21 January 2018

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

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21 January 2018

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

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ATR Regulates Fragile Site Stability

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A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

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Caffeine mimics adenine and 2′‐deoxyadenosine, both of which inhibit the guanine‐nucleotide exchange activity of RCC1 and the kinase activity of ATR

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Induction of alkaline phosphatase activity in HeLa cells. Inhibition by xanthine derivatives and thermostability studies

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Mechanism by which caffeine potentiates lethality of nitrogen mustard

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ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

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Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity

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Caffeine inhibits the checkpoint kinase ATM

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Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

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Cell cycle control and cancer

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Toward maintaining the genome: DNA damage and replication checkpoints

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Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

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Detection of ATM gene mutation in human glioma cell line M059J by a rapid frameshift/stop codon assay in yeast.

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ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation

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Molecular mechanisms of DNA repair inhibition by caffeine

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Methylxanthine inhibitors of phosphodiesterases

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Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34cdc2 kinase

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The Interaction of Caffeine with Ultra-violet-light-irradiated DNA

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Studies on DNA binding of caffeine and derivatives: evidence of intercalation by DNA-unwinding experiments

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Identifiers

10.1074/JBC.M307088200

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

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