(Q43803920)

27 November 2017

title

Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts (English)

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27 November 2017

6

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27 November 2017

Armogida M

1

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27 November 2017

Petit A

2

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27 November 2017

Vincent B

3

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27 November 2017

Scarzello S

4

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27 November 2017

da Costa CA

5

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27 November 2017

publication date

1 November 2001

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27 November 2017

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27 November 2017

volume

3

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27 November 2017

issue

11

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27 November 2017

page(s)

1030-1033

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The gene defects responsible for familial Alzheimer's disease

27 November 2017

cites work

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https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

The multiple paradoxes of presenilins

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Presenilin and gamma-secretase: structure meets function

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiop

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Apoptotic neurons in Alzheimer's disease frequently show intracellular Abeta42 labeling.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-1030

7 January 2021

Identifiers

DOI

10.1038/NCB1101-1030

1 reference

Dimensions Publication ID

27 November 2017

1024291354

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1 reference