(Q43043542)

English

Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1.

scientific article published on 29 December 2005

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1. (English)

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

author name string

Susan M Keating

1

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Kevin R Clark

2

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Lisa D Stefanich

3

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Fred Arellano

4

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Caroline P Edwards

5

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Sarah C Bodary

6

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Steven A Spencer

7

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Thomas R Gadek

8

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

James C Marsters

9

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Maureen H Beresini

10

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

publication date

29 December 2005

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Protein Science

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

15

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

2

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

290-303

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Therapeutic antagonists and the conformational regulation of the beta2 integrins

1 reference

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Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction

1 reference

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Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring.

1 reference

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Quantitative studies of antagonists for 5-hydroxytryptamine

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Some quantitative uses of drug antagonists

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Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation

1 reference

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Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases

1 reference

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Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule

1 reference

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Locking a leukocyte integrin with statins

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Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition

1 reference

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1 reference

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Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties

1 reference

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An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.

1 reference

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26 May 2018

Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead

1 reference

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26 May 2018

NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

1 reference

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Folding and function of I domain-deleted Mac-1 and lymphocyte function-associated antigen-1.

1 reference

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Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis

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Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain

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Transfer of a protein binding epitope to a minimal designed peptide

1 reference

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26 May 2018

Mapping the intercellular adhesion molecule-1 and -2 binding site on the inserted domain of leukocyte function-associated antigen-1.

1 reference

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1 reference

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The lymphocyte function-associated antigen 1 I domain is a transient binding module for intercellular adhesion molecule (ICAM)-1 and ICAM-3 in hydrodynamic flow

1 reference

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Signalling and adhesive properties of the integrin leucocyte function-associated antigen 1 (LFA-1).

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Identification of the binding site in intercellular adhesion molecule 1 for its receptor, leukocyte function-associated antigen 1.

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Integrin activation: the link between ligand binding and signal transduction

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Identification of methionine as the site of covalent attachment of a p-benzoyl-phenylalanine-containing analogue of substance P on the substance P (NK-1) receptor.

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A Binding Interface on the I Domain of Lymphocyte Function-associated Antigen-1 (LFA-1) Required for Specific Interaction with Intercellular Adhesion Molecule 1 (ICAM-1)

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Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily

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1 reference

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Identifiers

10.1110/PS.051583406

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

ResearchGate publication ID

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