(Q42829980)

8 November 2017

title

An analysis of Mek1 signaling in cell proliferation and transformation (English)

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8 November 2017

H Greulich

1

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8 November 2017

R L Erikson

series ordinal

2

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8 November 2017

language of work or name

English

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publication date

1 May 1998

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Journal of Biological Chemistry

8 November 2017

published in

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8 November 2017

volume

273

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8 November 2017

issue

21

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8 November 2017

page(s)

13280-13288

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Signal transduction. How receptors turn Ras on.

8 November 2017

cites work

1 reference

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Raf meets Ras: completing the framework of a signal transduction pathway

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The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product

21 January 2018

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Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase

21 January 2018

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Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells

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Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1.

21 January 2018

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Function of a human cyclin gene as an oncogene

21 January 2018

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Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1.

21 January 2018

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High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1.

21 January 2018

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Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.

21 January 2018

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Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation

21 January 2018

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Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

21 January 2018

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Constitutive activation of Mek1 by mutation of serine phosphorylation sites

21 January 2018

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Mek1 phosphorylation site mutants activate Raf-1 in NIH 3T3 cells

21 January 2018

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Phorbol ester stimulates a protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product

21 January 2018

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A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

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Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase

21 January 2018

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Biochemical and biological analysis of Mek1 phosphorylation site mutants

21 January 2018

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21 January 2018

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Cyclin D1 is a nuclear protein required for cell cycle progression in G1

21 January 2018

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p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

21 January 2018

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Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

21 January 2018

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p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

21 January 2018

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Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle

21 January 2018

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Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (G0 state) in fibroblasts

21 January 2018

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Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes.

21 January 2018

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Inhibition of platelet-derived growth factor- and epidermal growth factor-mediated mitogenesis and signaling in 3T3 cells expressing delta Raf-1:ER, an estradiol-regulated form of Raf-1.

21 January 2018

1 reference

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MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

21 January 2018

1 reference

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

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Cooperating oncogenes converge to regulate cyclin/cdk complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.21.13280

21 January 2018

Identifiers

DOI

10.1074/JBC.273.21.13280

1 reference

8 November 2017

1 reference