(Q42514385)

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Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis

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Europe PubMed Central

PubMed publication ID

1 November 2017

Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis (English)

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Europe PubMed Central

PubMed publication ID

1 November 2017

apoptotic process

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Teresita M. Bellido

3

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Teresita Bellido

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Europe PubMed Central

PubMed publication ID

1 November 2017

author name string

Lillian I Plotkin

1

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Europe PubMed Central

PubMed publication ID

1 November 2017

Stavros C Manolagas

2

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Europe PubMed Central

PubMed publication ID

1 November 2017

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publication date

20 June 2007

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Europe PubMed Central

PubMed publication ID

1 November 2017

number of pages

11

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Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

1 November 2017

282

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Europe PubMed Central

PubMed publication ID

1 November 2017

33

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Europe PubMed Central

PubMed publication ID

1 November 2017

24120-24130

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Europe PubMed Central

PubMed publication ID

1 November 2017

Mechanisms of glucocorticoid receptor action in noninflammatory and inflammatory cells

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Antiinflammatory action of glucocorticoids--new mechanisms for old drugs

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Cushing's syndrome

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The pathogenesis, epidemiology and management of glucocorticoid-induced osteoporosis

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Glucocorticoid-induced osteoporosis: an update

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Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone

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Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength

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Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone

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Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin

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Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase

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Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily

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RAFTK/Pyk2-mediated cellular signalling

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Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs

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The tyrosine kinase PYK-2/RAFTK regulates natural killer (NK) cell cytotoxic response, and is translocated and activated upon specific target cell recognition and killing

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Natriuretic peptides suppress vascular endothelial cell growth factor signaling to angiogenesis

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Transduction of cell survival signals by connexin-43 hemichannels

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Establishment of an osteocyte-like cell line, MLO-Y4.

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Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs

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Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.

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Prevention of glucocorticoid-induced apoptosis in osteocytes and osteoblasts by calbindin-D28k

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Fas/CD95 is associated with glucocorticoid-induced osteocyte apoptosis

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Glucocorticoid antagonists

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Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility

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PYK2 regulates SERCA2 gene expression in neonatal rat ventricular myocytes

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Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases

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Integrin signaling

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Integrins and anoikis

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Integrin regulation

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Integrins: bidirectional, allosteric signaling machines

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Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis

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Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss.

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Control of adhesion-dependent cell survival by focal adhesion kinase

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Identifiers

10.1074/JBC.M611435200

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

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