(Q40945077)

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Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.

scientific article published on July 1999

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9 December 2019

Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome (English)

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9 December 2019

Alzheimer's disease

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Tobias Hartmann

13

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9 December 2019

Stefan F Lichtenthaler

14

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9 December 2019

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9 December 2019

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9 December 2019

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G Christie

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9 December 2019

R E Markwell

2

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9 December 2019

C W Gray

3

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9 December 2019

L Smith

4

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9 December 2019

F Godfrey

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9 December 2019

F Mansfield

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9 December 2019

H Wadsworth

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9 December 2019

R King

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9 December 2019

M McLaughlin

9

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9 December 2019

D G Cooper

10

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9 December 2019

R V Ward

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9 December 2019

D R Howlett

12

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9 December 2019

K Beyreuther

15

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9 December 2019

J Underwood

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9 December 2019

S K Gribble

17

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9 December 2019

C L Masters

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9 December 2019

A Tamaoka

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9 December 2019

R L Gardner

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9 December 2019

A J Rivett

22

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9 December 2019

E H Karran

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9 December 2019

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1 July 1999

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9 December 2019

Journal of Neurochemistry

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9 December 2019

73

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9 December 2019

1

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9 December 2019

195-204

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9 December 2019

Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

1 reference

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21 January 2018

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

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Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides

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21 January 2018

Cleavage of amyloid beta peptide during constitutive processing of its precursor

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21 January 2018

Candidate .gamma.-Secretases in the Generation of the Carboxyl Terminus of the Alzheimer's Disease .beta.A4 Amyloid: Possible Involvement of Cathepsin D

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A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line

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Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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Carboxy-terminal truncation of long-tailed amyloid beta-peptide is inhibited by serine protease inhibitor and peptide aldehyde

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21 January 2018

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

1 reference

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21 January 2018

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

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Expression of human amyloid precursor protein ectodomains in Pichia pastoris: analysis of culture conditions, purification, and characterization

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21 January 2018

Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

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21 January 2018

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay

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21 January 2018

Proteolytic cleavage of the Alzheimer's disease amyloid A4 precursor protein

1 reference

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21 January 2018

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

1 reference

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21 January 2018

Calpain inhibitor I decreases beta A4 secretion from human embryonal kidney cells expressing beta-amyloid precursor protein carrying the APP670/671 double mutation

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Two-way cleavage of β-amyloid protein precursor by multicatalytic proteinase

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Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution

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Phosphorylation of proteasomes in mammalian cells. Identification of two phosphorylated subunits and the effect of phosphorylation on activity

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Phosphorylation of ATPase subunits of the 26S proteasome

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21 January 2018

Human brain peptidase activity with the specificity to generate the N-terminus of the Alzheimer β-amyloid protein from its precursor

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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Identification of the multicatalytic enzyme as a possible gamma-secretase for the amyloid precursor protein.

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Human IMR-32 neuroblastoma cells as a model cell line in Alzheimer's disease research.

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Alzheimer's amyloid precursor protein alpha-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: similarities to the angiotensin converting enzyme secretase

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Intracellular distribution of proteasomes

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Cathepsin G: localization in human cerebral cortex and generation of amyloidogenic fragments from the beta-amyloid precursor protein

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Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

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Specific inhibitor for prolyl endopeptidase suppresses the generation of amyloid beta protein in NG108-15 cells.

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Neuronal differentiation of Neuro 2a cells by lactacystin and its partial inhibition by the protein phosphatase inhibitors calyculin A and okadaic acid

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A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

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Evidence that Aβ42 is the real culprit in alzheimer's disease

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10.1046/J.1471-4159.1999.0730195.X

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Europe PubMed Central

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9 December 2019

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Europe PubMed Central

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9 December 2019

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